PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles
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DOI: 10.1007/s10562-018-2541-y
Abstract: AbstractA highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides… read more here.
Keywords: phi catalyzed; intramolecular oxidative; oxidative coupling; thiadiazole derivatives ... See more keywords
Computational studies of the mechanism of Pd-Catalyzed Intramolecular Friedel–Crafts allylic alkylation of phenols
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131146
Abstract: Abstract We previously reported a synthetic method of spirocyclohexadienones using an Pd-catalyzed intramolecular ipso-Friedel–Crafts allylic alkylation of para-substituted phenol derivatives. However, the mechanism for the step leading to spirocyclization and driving force behind the remarkably… read more here.
Keywords: crafts allylic; friedel; allylic alkylation; friedel crafts ... See more keywords
Palladium(II)-catalyzed intramolecular aminoacetoxylation of sugar derived alkenyl tosylsulfonamide: Total synthesis of l-deoxyallonojirimycin
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DOI: 10.1016/j.tetlet.2016.12.057
Abstract: Abstract Palladium catalyzed intramolecular aminoacetoxylation of d -ribose derived alkenyl tosylsulfonamide to deliver l -deoxyallonojirimycin in an overall yield of 19%. The preliminary screening of l -deoxyallonojirimycin against carbohydrate processing enzymes showed moderate inhibitory activity… read more here.
Keywords: intramolecular aminoacetoxylation; palladium catalyzed; alkenyl tosylsulfonamide; derived alkenyl ... See more keywords
Palladium-catalyzed intramolecular C H acylation of indoles with thioester
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2019.151061
Abstract: Abstract A palladium-catalyzed intramolecular C H acylation of indole with thioester is described, providing a direct and effective approach for the synthesis of the biologically active indole-indolone scaffolds. The method obviates the need for the… read more here.
Keywords: intramolecular acylation; acylation indoles; indoles thioester; palladium catalyzed ... See more keywords
Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02070
Abstract: We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with… read more here.
Keywords: hydroamination hydroalkoxylation; alkynes access; gold catalyzed; hydroalkoxylation alkynes ... See more keywords
Desymmetrization Process by Mg(II)-Catalyzed Intramolecular Vinylogous Michael Reaction.
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DOI: 10.1021/acs.orglett.0c03417
Abstract: Chiral magnesium catalyzed intramolecular vinylogous Michael reaction of novel cyclohexadienones via a desymmetrization process is reported. (R)-BINOL derived ligand and an achiral amide were employed in the current in situ generated magnesium catalyst, giving the… read more here.
Keywords: vinylogous michael; michael reaction; intramolecular vinylogous; desymmetrization process ... See more keywords
Phosphine-Catalyzed Intramolecular Vinylogous Aldol Reaction of α-Substituted Enones.
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DOI: 10.1021/acs.orglett.1c03913
Abstract: We demonstrate the first phosphine-catalyzed intramolecular vinylogous aldol reaction (IVAR) of α-substituted enones. This strategy provides access to various pentannulated (hetero)arenes and dibenzocycloheptanones incorporated with two contiguous stereocenters, one of which is an all-carbon quaternary… read more here.
Keywords: phosphine catalyzed; intramolecular vinylogous; vinylogous aldol; aldol reaction ... See more keywords
Chiral Brønsted Acid-Catalyzed Intramolecular Asymmetric Allylic Alkylation of Indoles with Primary Alcohols.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01253
Abstract: Herein, chiral Brønsted acid-catalyzed intramolecular asymmetric allylic alkylation of indoles with allylic primary alcohols is described. The allyl alcohols were directly employed as the allylic precursors in this metal-free protocol, without preactivation or any additional… read more here.
Keywords: intramolecular asymmetric; catalyzed intramolecular; chiral nsted; nsted acid ... See more keywords
Oxidative N-Heterocyclic Carbene-Catalyzed Intramolecular Friedel-Crafts Alkylation of Indoles for the Synthesis of Spirocyclic Indolenines.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01927
Abstract: The stereoselective intramolecular dearomatizing spirocyclization of indoles via oxidative N-heterocyclic carbene (NHC) catalysis to afford indolenines bearing an all-carbon quaternary center at the 3-position is reported. The reaction proceeds via the intramolecular nucleophilic addition of… read more here.
Keywords: catalyzed intramolecular; acyl azolium; carbene catalyzed; oxidative heterocyclic ... See more keywords
Sequential One-Pot Carbene-Catalyzed Intramolecular Stetter Reaction and Acid-Mediated Condensation: Access to Heteroatom Analogues of π-Extended Polyaromatic Hydrocarbons.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02693
Abstract: In this Letter, we disclose a simple and effective method to access a variety of phenanthro[9,10-b]furan and 1H-dibenzo[e,g]indole derivatives based on the design of a carbene-catalyzed intramolecular Stetter reaction followed by a Paal-Knorr reaction in… read more here.
Keywords: stetter reaction; catalyzed intramolecular; reaction; one pot ... See more keywords
Iridium-Catalyzed Intramolecular Asymmetric Allylation of Vinyl Benzoxazinones for the Synthesis of Chiral 4H-3,1-Benzoxazines via Kinetic Resolution.
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DOI: 10.1021/acs.orglett.3c00148
Abstract: Chiral benzoxazinones and 4H-3,1-benzoxazines as important motifs are widely found in abundant pharmaceuticals and biological molecules. We herein successfully developed the first kinetic resolution (KR) process of racemic benzoxazinones through Ir-catalyzed asymmetric intramolecular allylation, furnishing… read more here.
Keywords: intramolecular asymmetric; catalyzed intramolecular; allylation; iridium catalyzed ... See more keywords