Tuning the Reactivity of Ketones through Unsaturation: Construction of Cyclic and Acyclic Quaternary Stereocenters via Zn-ProPhenol Catalyzed Mannich Reactions
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DOI: 10.1021/acscatal.8b04685
Abstract: Introduction of unsaturation adjacent to the carbonyl drastically improves the reactivity of the Zn-ProPhenol catalyzed Mannich reactions between N-carbamoyl imines and a-branched ketones. Despite only a small change in the substrate acidity, the bimetallic catalyst… read more here.
Keywords: cyclic acyclic; acyclic quaternary; catalyzed mannich; quaternary stereocenters ... See more keywords