Zinc chloride catalyzed multicomponent synthesis of pyrazolopyridocoumarin scaffolds
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-019-1610-0
Abstract: An efficient synthesis of a series of pyrazolopyridocoumarins is reported by condensation of 4-hydroxycoumarin, benzaldehydes and 1-alkyl-5-amino-pyrazoles in the presence of 10 mol% zinc chloride in ethanol under reflux conditions through one-pot reaction. The significant… read more here.
Keywords: zinc chloride; reaction; structure; chloride catalyzed ... See more keywords
Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02578
Abstract: In the presence of a catalytic amount of Pd(OAc)2 and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and… read more here.
Keywords: fully substituted; multicomponent synthesis; synthesis fully; palladium catalyzed ... See more keywords
Synthesis of β-Polychlorinated Alkynes Enabled by Copper-Catalyzed Multicomponent Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01755
Abstract: Functional molecules bearing polychlorinated moieties usually play versatile roles in organic synthesis and biochemistry. A copper-catalyzed multicomponent polychloro-carboalkynylation of alkenes presents an efficient and operationally simple approach for the synthesis of β-polychlorinated alkynes. Mechanistic experiments… read more here.
Keywords: synthesis polychlorinated; copper; polychlorinated alkynes; catalyzed multicomponent ... See more keywords
Copper-Catalyzed Multicomponent Reactions of Intramolecular and Intermolecular Thiotrifluoromethylation of Alkenes: Access to CF3-Containing 2-Iminothiazolidines and Isothioureas.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02854
Abstract: A copper-catalyzed multicomponent reaction of secondary amines bearing allyl substitution, isothiocyanates, and Togni reagent II has been developed under Cs2CO3 in DCE at 75 °C. An intermolecular multicomponent reaction of thioureas, activated and unactivated alkenes,… read more here.
Keywords: multicomponent reactions; cf3 containing; reactions intramolecular; catalyzed multicomponent ... See more keywords
Direct Assembly of Polysubstituted Propiolamidinates via Palladium-Catalyzed Multicomponent Reaction of Isocyanides.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03201
Abstract: A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)-C(sp2) and C(sp2)═N bonds were constructed in one pot. This… read more here.
Keywords: reaction isocyanides; multicomponent reaction; via palladium; palladium catalyzed ... See more keywords
Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c07851
Abstract: A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of… read more here.
Keywords: coupling synthesis; multicomponent coupling; nickel catalyzed; catalyzed multicomponent ... See more keywords
Molecular iodine-catalyzed multicomponent synthesis of α-cyanopyrrolines with ambient air as the oxidant under neat conditions
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo01113d
Abstract: In this work, a variety of α-cyanopyrrolines were efficiently synthesized from alkenes, TMSCN and N,N-disubstituted formamides via molecular iodine-catalyzed tandem reaction under neat and mild conditions. This method applies ambient air as the sole oxidant… read more here.
Keywords: ambient air; iodine catalyzed; molecular iodine; catalyzed multicomponent ... See more keywords
General method for iron-catalyzed multicomponent radical cascades–cross-couplings
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abj6005
Abstract: Description Iron links a trio Iron holds particular appeal as a catalytic metal—it is safe and abundant, as well as a mainstay of enzymatic reactivity. Nonetheless, in synthetic construction of carbon-carbon bonds, modern chemists have… read more here.
Keywords: cross couplings; carbon; radical cascades; carbon carbon ... See more keywords