Ru(II)‐Catalyzed Ortho C−H Arylation of Heterocyclic Biaryls
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400463
Abstract: Ru(II)‐Pheox complexes are known catalysts for carbene insertion reactions. Herein we teach them a new trick: how to perform ortho C−H arylation processes! Our operationally simple protocol tolerates structurally diverse directing groups and both aryl… read more here.
Keywords: chemistry; arylation heterocyclic; ortho arylation; catalyzed ortho ... See more keywords
Ruthenium(II)-Catalyzed Ortho-C-H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01811
Abstract: Ruthenium(II)-catalyzed ortho-C-H alkylation of naphthylamines with diazo compounds for the synthesis of 2,2-disubstituted π-extended 3-oxindoles has been developed. The method represents the first example of C-H alkylation via carbenoid insertion in water as a sustainable… read more here.
Keywords: catalyzed ortho; naphthylamines diazo; alkylation naphthylamines; alkylation ... See more keywords
Iridium/Bipyridine-Catalyzed ortho-Selective C-H Borylation of Phenol and Aniline Derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02936
Abstract: An iridium-catalyzed ortho-selective C-H borylation of phenol and aniline derivatives has been successfully developed. Iridium/bipyridine-catalyzed C-H borylation generally occurred at the meta- and para-positions of aromatic substrates. Introduction of an electron-withdrawing substituent on the bipyridine-type… read more here.
Keywords: catalyzed ortho; borylation; selective borylation; ortho selective ... See more keywords
Manganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01770
Abstract: An efficient manganese-catalyzed ortho-C-H amidation of weakly coordinating aromatic ketones using the readily available sulfonyl azide as the amination reagent is developed. The key step is the ketone directed aromatic metalation using the in situ… read more here.
Keywords: catalyzed ortho; coordinating aromatic; weakly coordinating; manganese catalyzed ... See more keywords
Ruthenium-Catalyzed ortho- and meta-H/D Exchange of Arenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03955
Abstract: Ruthenium-catalyzed aromatic H/D exchange in [D4]acetic acid has been developed. By using N-heteroarenes as directing groups, both ortho and meta positions are selectively deuterated with high levels of D incorporation. Moreover, this strategy provides an… read more here.
Keywords: catalyzed ortho; exchange arenes; meta exchange; ortho meta ... See more keywords
Ruthenium-catalyzed ortho-selective CAr-H amination of heteroaryl arenes with di-tert-butyldiaziridinone.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc02499a
Abstract: Application of an oxidative amination reagent (di-tert-butyldiaziridinone) to the Ru3(CO)12-catalyzed ortho-selective CAr-H amination reaction is described. This strategy shows good functional group compatibility with various phenyl-substituted N-heterocycles, including biologically active substrates, thus providing synthetic potential… read more here.
Keywords: catalyzed ortho; selective car; amination; ortho selective ... See more keywords
2-Pyridone-Enabled Manganese-Catalyzed ortho-Selective Deuteration of Aromatic Amides with D₂O
Sign Up to like & getrecommendations! Published in 2025 at "Organic Chemistry Frontiers"
DOI: 10.1039/d5qo00606f
Abstract: We present a highly efficient and regioselective methodology for the synthesis of ortho-deuterated aromatic amides, utilizing Mn(CO)₅Br as the catalyst, 2-pyridone as the CMD base, and D₂O as the deuterium... read more here.
Keywords: enabled manganese; catalyzed ortho; manganese catalyzed; pyridone enabled ... See more keywords
Theoretical Study on the Copper-Catalyzed ortho-Selective C-H Functionalization of Naphthols with α-Phenyl-α-Diazoesters
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041767
Abstract: The aromatic C(sp2)-H functionalization of unprotected naphthols with α-phenyl-α-diazoesters under mild conditions catalyzed by CuCl and CuCl2 exhibits high efficiency and unique ortho-selectivity. In this study, the combination of density functional theory (DFT) calculations and… read more here.
Keywords: functionalization; phenyl diazoesters; catalyzed ortho; ortho selective ... See more keywords