Scandium-Catalyzed para-Selective Alkylation of Aromatic Amines with Alkenes.
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DOI: 10.1021/acs.orglett.9b03451
Abstract: An efficient para-alkylation of primary and secondary anilines with a variety of sterically encumbered alkenes using a simple β-diketiminato scandium catalyst is reported. This protocol features 100% atom economy, excellent chemo- and regioselectivity, broad substrate… read more here.
Keywords: scandium catalyzed; selective alkylation; para selective; alkylation aromatic ... See more keywords
Enantio- and Regioselective Ni-Catalyzed para-C-H Alkylation of Pyridines with Styrenes via Intermolecular Hydroarylation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04043
Abstract: Direct asymmetric functionalization of the pyridyl C-H bond represents a longstanding challenge in organic chemistry. We herein describe the first enantioselective para-C-H activation of pyridines through the use of a Ni-Al bimetallic catalyst system and… read more here.
Keywords: intermolecular hydroarylation; enantio regioselective; regioselective catalyzed; catalyzed para ... See more keywords
Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
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DOI: 10.1038/s41467-018-07069-1
Abstract: Selective creation of quaternary carbon centers has been a long-standing challenge in synthetic chemistry. We report here the chromium-catalyzed, para-selective formation of arylated quaternary carbon centers by alkylative reactions of benzamide derivatives with tertiary alkylmagnesium… read more here.
Keywords: chromium catalyzed; carbon; carbon centers; para selective ... See more keywords
Pd-Catalyzed para-selective C-H difluoromethylation of aromatic carbonyls.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc09129c
Abstract: A novel palladium catalyzed highly para-selective C-H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields.… read more here.
Keywords: para selective; selective difluoromethylation; aromatic carbonyls; catalyzed para ... See more keywords