Construction of carbocycles initiated by Cu-catalyzed radical reaction of Cl2C(CN)2
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.03.063
Abstract: Abstract A Cu-catalyzed radical reaction of Cl 2 C(CN) 2 was utilized for stereoselective conversion of unsaturated molecules into functionalized carbocycles. Chloromalononitrile radicals, generated by treating Cl 2 C(CN) 2 with catalytic amounts of CuCl… read more here.
Keywords: radical reaction; carbocycles initiated; catalyzed radical; initiated catalyzed ... See more keywords
N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Synthesis of δ-Ketocarbonyls.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01199
Abstract: An NHC-catalyzed radical relay enabled the vicinal alkylacylation of alkenes using aldehydes and tertiary α-bromo esters as a versatile route to δ-keto esters bearing an all-carbon quaternary center at the position α to the ester.… read more here.
Keywords: relay enabling; catalyzed radical; carbene catalyzed; radical relay ... See more keywords
Visible-Light-Driven Palladium-Catalyzed Radical Tandem Dearomatization of Indoles with Unactivated Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04390
Abstract: A mild visible-light-driven palladium-catalyzed radical tandem dearomatization of indoles with unactivated alkenes is described with moderate to good yields and good to excellent diastereoselectivities. Under visible-light irradiation, the photoexcited state of the palladium complex was… read more here.
Keywords: driven palladium; palladium catalyzed; light driven; visible light ... See more keywords
Cu-Catalyzed Radical Addition and Oxidation Cascade: Unsymmetrical Trimerization of Indole to Access Isotriazatruxene.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00180
Abstract: Herein we describe a Cu-catalyzed radical addition and oxidation cascade reaction for the chemo/regioselective synthesis of unsymmetrical indole trimers (isotriazatruxenes, i-TATs) from easily available starting materials. The i-TATs exhibited blue fluorescence in various solvents with… read more here.
Keywords: addition oxidation; catalyzed radical; radical addition; oxidation cascade ... See more keywords
Modular Access to 2-(Trifluoromethyl)pyrazolo[1,5-a]pyridines and Their Benzo Analogues through a Copper(I)-Catalyzed Radical Annulation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02500
Abstract: A mechanistically distinctive copper-catalyzed radical annulation to valuable 2-(trifluoromethyl)pyrazolo[1,5-a]pyridines and their benzo analogues has been described for the first time. Notably, the newly developed complementary process allows the synthesis of 4- or 6-substituted target molecular… read more here.
Keywords: pyridines benzo; catalyzed radical; radical annulation; pyrazolo pyridines ... See more keywords
Synthesis of Indeno[1,2-c]furans via Cobalt-Catalyzed Radical-Polar Crossover [3 + 2] Cycloaddition of o-Alkynylaryl β-Dicarbonyls.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03297
Abstract: Fused polycyclic furans are privileged structural scaffolds in materials chemistry, including organic semiconductors. Specifically, indeno[1,2-c]furans are an interesting type of polycyclic furans featuring a fused furan and indenone framework. Unfortunately, limited studies on their photophysical… read more here.
Keywords: cobalt catalyzed; polar crossover; catalyzed radical; indeno furans ... See more keywords
Synthetic Utility of Alkyl tert-Butyl Peroxides in a Copper-Catalyzed Radical Functionalization.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00574
Abstract: Alkyl tert-butyl peroxides are prepared from the corresponding tert-alkyl precursors and tert-butyl hydroperoxide in the presence of a promoter. These substrates can be utilized in a mild copper-catalyzed radical functionalization that utilizes several coupling partners… read more here.
Keywords: butyl peroxides; catalyzed radical; radical functionalization; tert butyl ... See more keywords
Copper-Catalyzed Radical Addition of Alkynols to Synthesize Difluoroheterocyclic Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00968
Abstract: A convenient method for the synthesis of fluorine-containing heterocyclic compounds was developed by a copper-catalyzed free radical addition reaction of alkynol and ethyl bromodifluoroacetate. This strategy involves copper-catalyzed free radical addition and molecular lactone exchange… read more here.
Keywords: addition alkynols; catalyzed radical; alkynols synthesize; radical addition ... See more keywords
Synthesis of β-Ketonitriles via N-Heterocyclic-Carbene-Catalyzed Radical Coupling of Aldehydes and Azobis(isobutyronitrile).
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01168
Abstract: Herein, an NHC (N-heterocyclic carbene)-catalyzed radical coupling reaction between aldehydes and azobis(isobutyronitrile) (AIBN) has been developed. This method provides an efficient and convenient approach for the synthesis of β-ketonitriles containing a quaternary carbon center (31… read more here.
Keywords: aldehydes azobis; azobis isobutyronitrile; catalyzed radical; carbene catalyzed ... See more keywords
Iron-Catalyzed Radical Hydrothiolation of gem-Difluoroalkenes.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02890
Abstract: gem-Difluoroalkenes serve as versatile intermediates in organofluorine chemistry, offering unique opportunities for synthetic elaboration. Leveraging the distinctive reactivity profile of gem-difluoroalkenes, we disclose herein an iron-catalyzed, regioselective hydrothiolation protocol that affords a diverse array of… read more here.
Keywords: gem difluoroalkenes; catalyzed radical; radical hydrothiolation; gem ... See more keywords
Photoinduced Copper-Catalyzed Radical Cascade Sonogashira-Type Coupling of Unsaturated Oxime Esters with Alkynes.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c03435
Abstract: A photoinduced copper-catalyzed radical cascade Sonogashira-type coupling of unsaturated oxime esters with terminal alkynes has been developed. The transformation proceeds under redox-neutral conditions via single-electron transfer (SET) from photoexcited Cu(I) acetylides, generating iminyl radicals that… read more here.
Keywords: cascade sonogashira; catalyzed radical; radical cascade; photoinduced copper ... See more keywords