Construction of carbocycles initiated by Cu-catalyzed radical reaction of Cl2C(CN)2
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.03.063
Abstract: Abstract A Cu-catalyzed radical reaction of Cl 2 C(CN) 2 was utilized for stereoselective conversion of unsaturated molecules into functionalized carbocycles. Chloromalononitrile radicals, generated by treating Cl 2 C(CN) 2 with catalytic amounts of CuCl… read more here.
Keywords: radical reaction; carbocycles initiated; catalyzed radical; initiated catalyzed ... See more keywords
N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Synthesis of δ-Ketocarbonyls.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01199
Abstract: An NHC-catalyzed radical relay enabled the vicinal alkylacylation of alkenes using aldehydes and tertiary α-bromo esters as a versatile route to δ-keto esters bearing an all-carbon quaternary center at the position α to the ester.… read more here.
Keywords: relay enabling; catalyzed radical; carbene catalyzed; radical relay ... See more keywords
Visible-Light-Driven Palladium-Catalyzed Radical Tandem Dearomatization of Indoles with Unactivated Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04390
Abstract: A mild visible-light-driven palladium-catalyzed radical tandem dearomatization of indoles with unactivated alkenes is described with moderate to good yields and good to excellent diastereoselectivities. Under visible-light irradiation, the photoexcited state of the palladium complex was… read more here.
Keywords: driven palladium; palladium catalyzed; light driven; visible light ... See more keywords
Cu-Catalyzed Radical Addition and Oxidation Cascade: Unsymmetrical Trimerization of Indole to Access Isotriazatruxene.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00180
Abstract: Herein we describe a Cu-catalyzed radical addition and oxidation cascade reaction for the chemo/regioselective synthesis of unsymmetrical indole trimers (isotriazatruxenes, i-TATs) from easily available starting materials. The i-TATs exhibited blue fluorescence in various solvents with… read more here.
Keywords: addition oxidation; catalyzed radical; radical addition; oxidation cascade ... See more keywords
Modular Access to 2-(Trifluoromethyl)pyrazolo[1,5-a]pyridines and Their Benzo Analogues through a Copper(I)-Catalyzed Radical Annulation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02500
Abstract: A mechanistically distinctive copper-catalyzed radical annulation to valuable 2-(trifluoromethyl)pyrazolo[1,5-a]pyridines and their benzo analogues has been described for the first time. Notably, the newly developed complementary process allows the synthesis of 4- or 6-substituted target molecular… read more here.
Keywords: pyridines benzo; catalyzed radical; radical annulation; pyrazolo pyridines ... See more keywords
Synthesis of Indeno[1,2-c]furans via Cobalt-Catalyzed Radical-Polar Crossover [3 + 2] Cycloaddition of o-Alkynylaryl β-Dicarbonyls.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03297
Abstract: Fused polycyclic furans are privileged structural scaffolds in materials chemistry, including organic semiconductors. Specifically, indeno[1,2-c]furans are an interesting type of polycyclic furans featuring a fused furan and indenone framework. Unfortunately, limited studies on their photophysical… read more here.
Keywords: cobalt catalyzed; polar crossover; catalyzed radical; indeno furans ... See more keywords
Synthetic Utility of Alkyl tert-Butyl Peroxides in a Copper-Catalyzed Radical Functionalization.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00574
Abstract: Alkyl tert-butyl peroxides are prepared from the corresponding tert-alkyl precursors and tert-butyl hydroperoxide in the presence of a promoter. These substrates can be utilized in a mild copper-catalyzed radical functionalization that utilizes several coupling partners… read more here.
Keywords: butyl peroxides; catalyzed radical; radical functionalization; tert butyl ... See more keywords
Copper-Catalyzed Radical Addition of Alkynols to Synthesize Difluoroheterocyclic Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00968
Abstract: A convenient method for the synthesis of fluorine-containing heterocyclic compounds was developed by a copper-catalyzed free radical addition reaction of alkynol and ethyl bromodifluoroacetate. This strategy involves copper-catalyzed free radical addition and molecular lactone exchange… read more here.
Keywords: addition alkynols; catalyzed radical; alkynols synthesize; radical addition ... See more keywords
Synthesis of β-Ketonitriles via N-Heterocyclic-Carbene-Catalyzed Radical Coupling of Aldehydes and Azobis(isobutyronitrile).
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01168
Abstract: Herein, an NHC (N-heterocyclic carbene)-catalyzed radical coupling reaction between aldehydes and azobis(isobutyronitrile) (AIBN) has been developed. This method provides an efficient and convenient approach for the synthesis of β-ketonitriles containing a quaternary carbon center (31… read more here.
Keywords: aldehydes azobis; azobis isobutyronitrile; catalyzed radical; carbene catalyzed ... See more keywords
Photoinduced Copper-Catalyzed Radical Aminocarbonylation of Cycloketone Oxime Esters
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b02830
Abstract: A visible light-induced and exogenous photosensitizer-free, copper-catalyzed radical aminocarbonylation of cycloketone oxime esters with CO gas and amines is developed. The mild catalytic system involving CuCl and N,N,N-tridentate ligand shows good reactivity and chemoselectivity, and… read more here.
Keywords: catalyzed radical; oxime esters; cycloketone oxime; copper catalyzed ... See more keywords
Asymmetric Ni-catalyzed Radical Relayed Reductive Coupling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c05254
Abstract: Alkene dicarbofunctionalizations represent streamline the construction of aliphatic structures and have thus been the subject of intense research efforts. Despite significant progress, catalytic asymmetric variants remain scarce. Inspired by the advantages of reductive cross-coupling approaches,… read more here.
Keywords: methodology; radical relayed; catalyzed radical; asymmetric catalyzed ... See more keywords