Rh(III)-Catalyzed Redox-Neutral [4+2] Annulation for Direct Assembly of 3-Acyl Isoquinolin-1(2H)-ones as Potent Antitumor Agents.
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DOI: 10.1002/cplu.201900616
Abstract: By virtue of an efficient rhodium(III)-catalyzed redox-neutral C-H activation/ring-opening of a strained ring/[4+2] annulation cascade of N-methoxybenzamides with propargyl cycloalkanols, diverse 3-acyl isoquinolin-1(2H)-ones were directly obtained in good yields and with excellent functional group compatibility.… read more here.
Keywords: annulation; iii catalyzed; redox neutral; isoquinolin ones ... See more keywords
Photoredox-Catalyzed Redox-Neutral Decarboxylative C-H Acylations of Coumarins with α-Keto Acid.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00632
Abstract: A novel and green photocatalytic strategy for the synthesis of C-4-acylated coumarins with α-keto acids and 3-nitrocoumarin has been developed. This operationally simple protocol works under mild reaction conditions, providing convenient access to 4-acyl coumarin… read more here.
Keywords: coumarins keto; decarboxylative acylations; neutral decarboxylative; redox neutral ... See more keywords
Cu-Catalyzed Redox-Neutral Ring Cleavage of Cycloketone O-Acyl Oximes: Chemodivergent Access to Distal Oxygenated Nitriles.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03707
Abstract: A chemodivergent copper-catalyzed ring opening of cycloketone oximes via radical-mediated C-C bond cleavage under redox-neutral conditions is described. This method allows the divergent synthesis of γ- and δ-acyloxylated, alkoxylated, and hydroxylated nitriles while avoiding the… read more here.
Keywords: cycloketone; redox neutral; ring cleavage; catalyzed redox ... See more keywords
Direct β-Alkylation of Ketones and Aldehydes via Pd-Catalyzed Redox Cascade.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b03530
Abstract: We report a direct β-alkylation of ketones and aldehydes with simple alkyl bromides through a Pd-catalyzed redox-cascade strategy. The use of a Cu cocatalyst is important for improved efficiency. The reaction is redox-neutral, without the… read more here.
Keywords: ketones aldehydes; alkylation; catalyzed redox; redox cascade ... See more keywords
An organophotoredox-catalyzed redox-neutral cascade involving N-(acyloxy)phthalimides and allenamides: synthesis of indoles.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc05397c
Abstract: An organophotoredox-catalyzed radical cascade of allenamides and alkyl N-(acyloxy)phthalimides for the synthesis of indoles is documented. The method features mild and robust reaction conditions, and exhibits broad scope. The tandem process enriches the limited repertoire… read more here.
Keywords: acyloxy phthalimides; organophotoredox catalyzed; cascade; synthesis indoles ... See more keywords
An organophotoredox-catalyzed redox-neutral cascade involving N-(acyloxy)phthalimides and maleimides
Sign Up to like & getrecommendations! Published in 2021 at "Organic chemistry frontiers"
DOI: 10.1039/d1qo00170a
Abstract: An organophotoredox-catalyzed reduction/addition/oxidation cascade of N-protected maleimides and N-(acyloxy)phthalimides is documented. The mild and efficient redox-neutral process involves the hitherto unknown Giese-type addition of aryloxy-alkyl radicals on N-protected maleimides and a successive oxidation allowing an… read more here.
Keywords: neutral cascade; organophotoredox catalyzed; acyloxy phthalimides; redox neutral ... See more keywords
Copper-catalyzed redox-neutral regioselective chlorosulfonylation of vinylarenes
Sign Up to like & getrecommendations! Published in 2021 at "Reaction Chemistry and Engineering"
DOI: 10.1039/d1re00188d
Abstract: A simple Cu(OTf)2-catalyzed alkene chlorosulfonylation reaction is developed. read more here.
Keywords: chlorosulfonylation; regioselective chlorosulfonylation; neutral regioselective; redox neutral ... See more keywords
Rh(III)-Catalyzed Redox-Neutral C–H Activation/Annulation of Oxadiazolones with Sulfoxonium Ylides to access oxadiazoloisoquinolinone
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DOI: 10.1039/d4nj05391e
Abstract: Here, we developed a synthetic route for oxadiazolone-fused isoquinoline derivatives through Rh(III)-catalyzed [4+2] redox-neutral annulations of aryl oxadiazolones with sulfoxonium ylides, followed by a second C–H activation to produce acymethylation... read more here.
Keywords: sulfoxonium ylides; redox neutral; oxadiazolones sulfoxonium; catalyzed redox ... See more keywords
Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides
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DOI: 10.1055/a-2343-0676
Abstract: Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs and bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed,… read more here.
Keywords: neutral multifluoroalkenylation; redox neutral; multifluoroalkenylation benzamides; catalyzed redox ... See more keywords
Copper-Catalyzed Redox Coupling of Nitroarenes with Sodium Sulfinates
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DOI: 10.3390/molecules24071407
Abstract: A simple copper-catalyzed redox coupling of sodium sulfinates and nitroarenes is described. In this process, abundant and stable nitroarenes serve as both the nitrogen sources and oxidants, and sodium sulfinates act as both reactants and… read more here.
Keywords: coupling nitroarenes; redox coupling; sodium sulfinates; catalyzed redox ... See more keywords