Cu(II)-Catalyzed, Site Selective Sulfoximination to Indole and Indolines via Dual C-H/N-H Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02817
Abstract: A copper-catalyzed protocol furnishing N-arylated sulfoximines has been developed via dual N-H/C-H activation. Arylalkyl- and less reactive diarylsulfoximines were efficiently coupled with privileged scaffolds like indolines, indoles, and N-Ar-7-azaindoles. Sulfoximines based on medicinally relevant scaffolds… read more here.
Keywords: selective sulfoximination; dual activation; site selective; catalyzed site ... See more keywords
Silver-Catalyzed Site-Selective Ring-Opening and C-C Bond Functionalization of Cyclic Amines: Access to Distal Aminoalkyl-Substituted Quinones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01496
Abstract: Distal aminoalkyl-substituted quinones have been efficiently prepared through silver-catalyzed site-selective deconstruction and C-C bond transformation of unstrained N-acylated cyclic amines. This method enjoys mild reaction conditions, high selectivity, a broad scope of substrates, and a… read more here.
Keywords: distal aminoalkyl; silver catalyzed; site selective; substituted quinones ... See more keywords
PdII-Catalyzed Site-selective β- and γ-C(sp3)-H Arylation of Primary Aldehydes Controlled by Transient Directing Groups.
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DOI: 10.1021/jacs.1c13586
Abstract: Pd(II)-catalyzed site-selective β- and γ-C(sp3)-H arylation of primary aldehydes is developed by rational design of L,X-type transient directing groups (TDG). External 2-pyridone ligands are identified to be crucial for the observed reactivity. By minimizing the… read more here.
Keywords: arylation primary; selective sp3; catalyzed site; sp3 arylation ... See more keywords
The underlying factors controlling the Pd-catalyzed site-selective alkenylation of aliphatic amines.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt01568b
Abstract: The Pd(ii)-catalyzed site-selective δ-C(sp3)-H alkenylation in the presence of more accessible γ-C(sp3)-H bonds is investigated by DFT calculations. Migratory insertion is found to be both the rate-limiting and the selectivity-determining step. The origin of the… read more here.
Keywords: factors controlling; site selective; underlying factors; catalyzed site ... See more keywords
Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines
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DOI: 10.1055/a-1506-3884
Abstract: We report a convenient method for the highly site selective borylation of 8-arylquinoline. The reaction proceeds smoothly in presence of catalytic amount of [Ir(OMe)(cod)]2 and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The… read more here.
Keywords: selective borylation; iridium catalyzed; site selective; catalyzed site ... See more keywords