Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
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DOI: 10.1021/jacs.2c03313
Abstract: A key step in the biosynthesis of numerous polyketides is the stereospecific formation of a spiroacetal (spiroketal). We report here that spiroacetal formation in the biosynthesis of the macrocyclic polyketides ossamycin and oligomycin involves catalysis… read more here.
Keywords: formation polyketide; biosynthesis; enzyme catalyzed; catalyzed spiroacetal ... See more keywords