Resolution of (R,S)-1-(4-methoxyphenyl)ethanol by lipase-catalyzed stereoselective transesterification and the process optimization.
Sign Up to like & getrecommendations! Published in 2021 at "Chirality"
DOI: 10.1002/chir.23402
Abstract: An efficient lipase-catalyzed stereoselective transesterification reaction system was established for resolution of 1-(4-methoxyphenyl)ethanol (MOPE) enantiomers. A series of lipases were tested and compared. The immobilized lipase Novozym 40086 is selected as the best choice. The… read more here.
Keywords: lipase; methoxyphenyl ethanol; stereoselective transesterification; catalyzed stereoselective ... See more keywords
Copper(I)-catalyzed stereoselective hydrogenation of 1,3-diynes and enynes
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.05.029
Abstract: A stereoselective hydrogenation of 1,3-diynes with an air-stable copper(I)/N-heterocyclic carbene complex, [IPrCuOH], has been developed. The corresponding products, 1,3-dienes, are obtained in a stereoselective manner depending on their substitution pattern: Diaryl-diynes yield E,E-1,3-dienes, whereas dialkyl-diynes… read more here.
Keywords: stereoselective hydrogenation; hydrogenation; catalyzed stereoselective; hydrogenation diynes ... See more keywords
Palladium-Catalyzed Stereoselective Hydrodefluorination of Tetrasubstituted gem-Difluoroalkenes.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01813
Abstract: A highly stereoselective palladium(0)-catalyzed hydrodefluorination (HDF) of tetrasubstituted gem-difluoroalkenes is developed. By using catalytic Pd(PPh3)4 (2.5-5 mol %) and hydrosilane Me2PhSiH, various trisubstituted terminal (E)-monofluoroalkenes can be synthesized with excellent E/Z selectivity (>99:1) and good… read more here.
Keywords: tetrasubstituted gem; catalyzed stereoselective; gem difluoroalkenes; palladium catalyzed ... See more keywords
Bismuth-Catalyzed Stereoselective 2-Deoxyglycosylation of Disarmed/Armed Glycal Donors.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04008
Abstract: Bi(OTf)3 promoted direct and highly stereoselective glycosylation of "disarmed" and "armed" glycals to synthesize 2-deoxyglycosides has been reported. The tunable and solvent-controlled chemoselective activation of deactivated glycal donors distinguishing the competitive Ferrier and 1,2-addition pathways… read more here.
Keywords: deoxyglycosylation disarmed; disarmed armed; catalyzed stereoselective; stereoselective deoxyglycosylation ... See more keywords
Palladium-Catalyzed Stereoselective Defluorosilylation of gem-Difluoroalkenes for the Synthesis of Tetrasubstituted Monofluorinated Vinylsilanes.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00718
Abstract: Stereoselective synthesis of tetrasubstituted vinylsilanes is a challenging task. We herein report a novel palladium(0)-catalyzed defluorosilylation of β,β-difluoroacrylates to access tetrasubstituted vinylsilanes containing the monofluoroalkene motif in excellent diastereoselectivities (>99:1). This is our first example… read more here.
Keywords: stereoselective defluorosilylation; palladium catalyzed; catalyzed stereoselective; synthesis tetrasubstituted ... See more keywords
Cu-Catalyzed Stereoselective Borylation of gem-Difluoroalkenes with B2pin2.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01430
Abstract: A novel and efficient method for the synthesis of (Z)-fluorinated alkenylboronic acid pinacol esters via Cu-catalyzed stereoselective borylation of gem-difluoroalkenes using bis(pinacolato)diboron (B2pin2) as the boron source with the assistance of NaOtBu and Xantphos at… read more here.
Keywords: gem difluoroalkenes; borylation gem; catalyzed stereoselective; stereoselective borylation ... See more keywords
Carbon Dioxide-Catalyzed Stereoselective Cyanation Reaction
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b01087
Abstract: We report a Michael-type cyanation reaction of coumarins by using CO2 as a catalyst. The delivery of the nucleophilic cyanide was realized by catalytic amounts of CO2, which forms cyanoformate and ... read more here.
Keywords: dioxide catalyzed; cyanation; catalyzed stereoselective; cyanation reaction ... See more keywords
Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b05680
Abstract: A three-component coupling of aryl bromides, arylboron reagents, and alkenylarenes is presented. The method tolerates a variety of substitution patterns on all of the components. In particular, 1,2-disubstituted alkenylarenes are suitable and undergo highly diastereoselective… read more here.
Keywords: stereoselective diarylation; catalyzed stereoselective; diarylation; diarylation alkenylarenes ... See more keywords
Gold-catalyzed stereoselective cycloisomerization of allenoic acids for two types of common natural γ-butyrolactones
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03894-6
Abstract: Abstractγ-(E)-Vinylic and γ-alkylic γ-butyrolactones are two different types of lactones existing extensively in animals and plants and many of them show interesting biological activities. Nature makes alkylic γ-butyrolactones by many different enzymatic lactonization processes. Scientists… read more here.
Keywords: catalyzed stereoselective; cycloisomerization; allenoic acids; cycloisomerization allenoic ... See more keywords
Cu(I)-Catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition reaction
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c8qo00664d
Abstract: An efficient Cu(I)-catalyzed stereoselective synthesis of trisubstituted Z-enol esters via interrupting the 1,3-O-transposition process is reported. This method provided a convenient approach to highly functionalized Z-enol esters with mild reaction conditions and wide substrate scope. read more here.
Keywords: trisubstituted enol; esters via; stereoselective synthesis; catalyzed stereoselective ... See more keywords
N-Allylbenzimidazole as a strategic surrogate in Rh-catalyzed stereoselective trans-propenylation of aryl C(sp2)-H bond.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc06048e
Abstract: A Rh-catalyzed C(sp2)-H propenylation has been reported by taking N-allyl benzimidazole as an allylamine congener. This transformation has been observed for the first time, where a tandem process of C-H allylation followed by alkene isomerization… read more here.
Keywords: catalyzed stereoselective; stereoselective trans; surrogate catalyzed; allylbenzimidazole strategic ... See more keywords