P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.
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DOI: 10.1021/acs.biochem.8b00623
Abstract: Leinamycin (LNM) is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140. Both in vivo and in vitro characterization of the LNM biosynthetic machinery have established the formation of the 18-membered macrolactam backbone and the… read more here.
Keywords: biosynthesis; lnma lnmz; tailoring steps; catalyzed tailoring ... See more keywords