Gelastic Cataplexy in Niemann Pick Type C
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.12786
Abstract: Cataplexy delineates a brief episode of generalized loss of muscle tone without alteration in consciousness. When cataplexy is triggered by laughter, the term “gelastic” is utilized. Gelastic cataplexy and vertical supranuclear gaze palsy (VSGP) are… read more here.
Keywords: pick type; cataplexy niemann; gelastic cataplexy; cataplexy ... See more keywords
Cataplexy in Patients Harboring the KCNMA1 p.N999S Mutation
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13024
Abstract: KCNMA1 codes for the pore-forming alpha-subunit of the voltageand calcium-sensitive potassium channel (BK channel). BK channel dysfunction has previously been implicated in paroxysmal dyskinesia. We describe 3 unrelated patients with cataplexy, all sharing the same… read more here.
Keywords: developmental delay; kcnma1; patient year; year old ... See more keywords
Cataplexy and Its Mimics: Clinical Recognition and Management
Sign Up to like & getrecommendations! Published in 2017 at "Current Treatment Options in Neurology"
DOI: 10.1007/s11940-017-0459-0
Abstract: Opinion statementThis review describes the diagnosis and management of cataplexy: attacks of bilateral loss of muscle tone, triggered by emotions and with preserved consciousness. Although cataplexy is rare, its recognition is important as in most… read more here.
Keywords: active motor; management cataplexy; cataplexy mimics; management ... See more keywords
Therapy for Cataplexy
Sign Up to like & getrecommendations! Published in 2020 at "Current Treatment Options in Neurology"
DOI: 10.1007/s11940-020-0619-5
Abstract: Purpose of the review Cataplexy, an involuntary loss of muscle activity triggered by strong emotions is the most impressive symptom in narcolepsy. This review gives an overview of the current understanding of cataplexy and its… read more here.
Keywords: treatment; cataplexy; therapy cataplexy;
Deep brain stimulation of hypothalamus for narcolepsy-cataplexy in mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain Stimulation"
DOI: 10.1016/j.brs.2020.04.006
Abstract: BACKGROUND Narcolepsy type 1 (NT1, narcolepsy with cataplexy) is a disabling neurological disorder caused by loss of excitatory orexin neurons from the hypothalamus and is characterized by decreased motivation, sleep-wake fragmentation, intrusion of rapid-eye-movement sleep… read more here.
Keywords: cataplexy; stimulation; mice; narcolepsy ... See more keywords
Neurobiology of cataplexy.
Sign Up to like & getrecommendations! Published in 2021 at "Sleep medicine reviews"
DOI: 10.1016/j.smrv.2021.101546
Abstract: Cataplexy is the pathognomonic and the most striking symptom of narcolepsy. It has originally been, and still is now, widely considered as an abnormal manifestation of rapid eye movement (REM) sleep during wakefulness due to… read more here.
Keywords: neurobiology cataplexy; neurobiology; rem sleep; cataplexy ... See more keywords
Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(16)30333-7
Abstract: BACKGROUND Histaminergic neurons are crucial to maintain wakefulness, but their role in cataplexy is unknown. We assessed the safety and efficacy of pitolisant, a histamine H3 receptor inverse agonist, for treatment of cataplexy in patients… read more here.
Keywords: trial; treatment; group; patients narcolepsy ... See more keywords
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19862-y
Abstract: Loss of muscle tone triggered by emotions is called cataplexy and is the pathognomonic symptom of narcolepsy, which is caused by hypocretin deficiency. Cataplexy is classically considered to be an abnormal manifestation of REM sleep… read more here.
Keywords: rem sleep; interactions serotonergic; knockout mice; hypocretinergic interactions ... See more keywords
006 The effect of sodium oxybate on cataplexy in orexin knockout mice
Sign Up to like & getrecommendations! Published in 2021 at "Sleep"
DOI: 10.1093/sleep/zsab072.005
Abstract: Narcolepsy is a neurological disorder that is characterized by the loss of orexin neurons in the lateral hypothalamus. Cataplexy is a symptom of narcolepsy and is identified by a sudden loss of muscle tone during… read more here.
Keywords: effect; mice; cataplexy; mechanism ... See more keywords
Intermediate hypocretin-1 cerebrospinal fluid levels and typical cataplexy: their significance in the diagnosis of narcolepsy type 1
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac052
Abstract: Abstract Study Objectives The diagnosis of narcolepsy type 1 (NT1) is based upon the presence of cataplexy and/or a cerebrospinal fluid (CSF) hypocretin-1/orexin-A level ≤ 110 pg/mL. We determined the clinical and diagnostic characteristics of patients with… read more here.
Keywords: hypocretin; hypocretin levels; intermediate hypocretin; typical cataplexy ... See more keywords
0039 Investigating the role of striatal dopamine in sleep and narcolepsy-cataplexy
Sign Up to like & getrecommendations! Published in 2023 at "SLEEP"
DOI: 10.1093/sleep/zsad077.0039
Abstract: Dopamine release in the striatum is known to govern reward, motor, and sleep behaviors. There also exists a link between pharmacological manipulation of dopamine receptors and cataplexy occurrence, yet the precise spatial and temporal dynamics… read more here.
Keywords: dopamine release; release; stimulation; cataplexy ... See more keywords