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   Articles with "cataract formation" as a keyword



Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2410860122

Abstract: Human γD-crystallin, a monomeric protein abundant in the eye lens nucleus, must remain stably folded for an individual’s entire lifetime to avoid aggregation and protein deposition-associated cataract formation. γD-crystallin contains two homologous domains, an N-terminal… read more here.

Keywords: terminal domain; protein; variants crystallin; native conditions ... See more keywords

Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway

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recommendations! Published in 2017 at "Cellular Physiology and Biochemistry"

DOI: 10.1159/000477330

Abstract: Background/Aims: KCNQ1OT1 regulates the expression of tissue-specific imprinted genes within the Kcnq1 domain. Imprinted genes are positive regulators of apoptosis, one of the forms of cell death related to cataract formation, and thus may provide… read more here.

Keywords: caspase; cataract formation; non coding; expression ... See more keywords

Drugs associated with cataract formation represent an unmet need in cataract research

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recommendations! Published in 2022 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2022.947659

Abstract: Decreased light transmittance through the ocular lens, termed cataract, is a leading cause of low vision and blindness worldwide. Cataract causes significantly decreased quality of life, particularly in the elderly. Environmental risk factors, including aging,… read more here.

Keywords: drugs associated; prescription; cataract formation; drug ... See more keywords

Exploring Angiotensin II and Oxidative Stress in Radiation-Induced Cataract Formation: Potential for Therapeutic Intervention

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recommendations! Published in 2024 at "Antioxidants"

DOI: 10.3390/antiox13101207

Abstract: Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require a deep understanding of the mechanisms… read more here.

Keywords: radiation induced; stress; oxidative stress; cataract formation ... See more keywords