Identification of ortho catechol-containing isoflavone as a privileged scaffold that directly prevents the aggregation of both amyloid β plaques and tau-mediated neurofibrillary tangles and its in vivo evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105022
Abstract: In this study, polyhydroxyisoflavones that directly prevent the aggregation of both amyloid β (Aβ) and tau were expediently synthesized via divergent Pd(0)-catalyzed Suzuki-Miyaura coupling and then biologically evaluated. By preliminary structure-activity relationship studies using thioflavin… read more here.
Keywords: aggregation; tau; ortho catechol; catechol containing ... See more keywords
Toward Protein-Repellent Surface Coatings from Catechol-Containing Cationic Poly(2-ethyl-2-oxazoline).
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c22518
Abstract: Inspired by mussel proteins that enable surface binding in harsh marine environments, we envisioned a platform of protein-repellent macromolecules based on poly(2-ethyl-2-oxazoline) carrying catechol and cationic functional groups. To facilitate surface attachment, catechol units were… read more here.
Keywords: poly ethyl; protein repellent; surface; catechol containing ... See more keywords
In-Situ Deactivation of Catechol-Containing Adhesive using Electrochemistry.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11266
Abstract: Marine mussels secret catechol-containing adhesive proteins that enable these organisms to bind to various surfaces underwater. Synthetic mimics of these proteins have been created to function as adhesives and coatings for a wide range of… read more here.
Keywords: mechanics; electricity; catechol containing; catechol ... See more keywords
Catechol-Containing Schiff Bases on Thiacalixarene: Synthesis, Copper (II) Recognition, and Formation of Organic-Inorganic Copper-Based Materials
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082334
Abstract: For the first time, a series of catechol-containing Schiff bases, tetrasubstituted at the lower rim thiacalix[4]arene derivatives in three stereoisomeric forms, cone, partial cone, and 1,3-alternate, were synthesized. The structure of the obtained compounds was… read more here.
Keywords: schiff bases; organic inorganic; copper; containing schiff ... See more keywords