Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.05.007
Abstract: Protein tyrosine phosphatases 1B (PTP1B) is a promising and validated therapeutic target to effectively treat T2DM and obesity. However, the development of charged PTP1B inhibitors was restricted due to their low cell permeability and poor… read more here.
Keywords: design synthesis; biological evaluation; uncharged catechol; evaluation uncharged ... See more keywords
Antioxidant and antihyperlipidemic activities of catechol derivatives and biflavonoid isolated from Semecarpus anacardium seeds.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology mechanisms and methods"
DOI: 10.1080/15376516.2021.1973170
Abstract: Semecarpus anacardium Linn. (Family: Anacardiaceae), commonly known marking nuts has been used in various traditional system of medicines for various ailments (such as antiatherogenic, antiinflammatory, antimicrobial, hypoglycemic, anticarcinogenic etc) since ancient times.Based on the wide… read more here.
Keywords: hypercholesterolemic rats; biflavonoid isolated; semecarpus anacardium; derivatives biflavonoid ... See more keywords