Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans
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DOI: 10.1007/s00213-019-05273-5
Abstract: AbstractRationaleThe catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.ObjectiveThis study was designed to evaluate the effect of (1) a functional polymorphism and… read more here.
Keywords: methyl transferase; delta tetrahydrocannabinol; study; acute response ... See more keywords
Effects of Catechol O-Methyl Transferase Inhibition on Anti-Inflammatory Activity of Luteolin Metabolites.
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DOI: 10.1111/1750-3841.13620
Abstract: Although luteolin is known to have potent anti-inflammatory activities, much less information has been provided on such activities of its hepatic metabolites. Luteolin was subjected to hepatic metabolism in HepG2 cells either without or with… read more here.
Keywords: anti inflammatory; methyl transferase; luteolin metabolites; catechol methyl ... See more keywords
1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against Parkinson’s Disease
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DOI: 10.3390/molecules27092816
Abstract: Two analogues of tolcapone where the nitrocatechol group has been replaced by a 1-hydroxy-2(1H)-pyridinone have been designed and synthesised. These compounds are expected to have a dual mode of action both beneficial against Parkinson’s disease:… read more here.
Keywords: parkinson disease; hydroxy pyridinone; methyl transferase; catechol methyl ... See more keywords