Interaction between catechol‐O‐methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post‐traumatic stress disorder
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1733
Abstract: Suicidal behavior of post‐traumatic stress disorder (PTSD) patients is influenced by genetic and environmental factors. The catechol‐O‐methyltransferase (COMT) gene has been known to be associated with suicidal ideation. The present study aimed to explore the… read more here.
Keywords: post traumatic; ideation; stress disorder; catechol methyltransferase ... See more keywords
Relations between catechol-O-methyltransferase Val158Met genotype and inhibitory control development in childhood.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental psychobiology"
DOI: 10.1002/dev.21901
Abstract: The Val158Met rs4680 single-nucleotide polymorphism (SNP) at the catechol-O-methyltransferase (COMT) gene, primarily involved in dopamine breakdown within prefrontal cortex, has shown relations with inhibitory control (IC) in both adults and children. However, little is known… read more here.
Keywords: comt genotype; childhood; catechol methyltransferase; performance ... See more keywords
Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of l-dopa and its metabolite 3-O-methyldopa in combination with entacapone
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-020-02267-y
Abstract: In the pharmacotherapy of patients with Parkinson’s disease (PD), entacapone reduces the peripheral metabolism of l-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t1/2) of l-dopa and increasing the area under the concentration curve (AUC).… read more here.
Keywords: catechol methyltransferase; val158met polymorphism; dopa; entacapone ... See more keywords
Purification of Histidine-Tagged Membrane-Bound Catechol-O-Methyltransferase from Detergent-Solubilized Pichia pastoris Membranes
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-017-3453-5
Abstract: Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine catabolism that is key for the treatment of different neurologic disorders. Actually, there are still unmet needs concerning the development of more selective membrane-bound COMT (hMBCOMT) downstream… read more here.
Keywords: pastoris membranes; membrane bound; catechol methyltransferase; hmbcomt ... See more keywords
Thermal behavior of entacapone, a catechol-O-methyltransferase inhibitor used in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-018-7097-y
Abstract: Entacapone, a selective and reversible inhibitor of catechol-O-methyltransferase, is used in the treatment of Parkinson’s disease in combination with levodopa/carbidopa to treat the symptoms of end-of-dose “wearing-off” effect. Considering that new formulations are researched constantly,… read more here.
Keywords: catechol methyltransferase; inhibitor; parkinson disease;
Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0668-2
Abstract: The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigated the possible structural covariance networks that may be… read more here.
Keywords: seed; alzheimer disease; catechol methyltransferase; polymorphism ... See more keywords
Interaction of silver nanoparticles with catechol O-methyltransferase: Spectroscopic and simulation analyses
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101013
Abstract: Catechol O-methyltransferase, an enzyme involved in the metabolism of catechol containing compounds, catalyzes the transfer of a methyl group between S-adenosylmethionine and the hydroxyl groups of the catechol. Furthermore it is considered a potential drug… read more here.
Keywords: interaction silver; catechol methyltransferase; methyltransferase; spectroscopy ... See more keywords
Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.07.015
Abstract: Catechol O-methyltransferase (COMT) inhibitors are valuable co-adjuvant drugs in the clinical management of Parkinson's disease (PD), and recent data also suggest therapeutic benefits in other neurological disorders associated with dopamine depletion. However, the relationship between… read more here.
Keywords: catechol methyltransferase; replace tolcapone; comt inhibitors; inhibitors replace ... See more keywords
Chemical Profiles of Korean Bee Pollens and Their Catechol-O-methyltransferase Inhibitory Activities.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07778
Abstract: Bee pollen is an apicultural product collected by honeybees from flower stamens and is consumed to help maintain a healthy diet. In this study, the chemical profiles of 11 Korean bee pollens were investigated using… read more here.
Keywords: profiles korean; catechol methyltransferase; chemical profiles; bee pollens ... See more keywords
Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01126
Abstract: A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase… read more here.
Keywords: hydroxyquinolines inhibitors; optimization hydroxyquinolines; inhibitors catechol; catechol methyltransferase ... See more keywords
Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.9b00345
Abstract: A series of bicyclic pyridones were identified as potent inhibitors of catechol O-methyltransferase (COMT). Substituted benzyl groups attached to the basic nitrogen of the core scaffold gave the most potent inhibitors within this series. Rat… read more here.
Keywords: evaluation bicyclic; inhibitors catechol; catechol methyltransferase; bicyclic hydroxypyridones ... See more keywords