Role of epigenetic regulation on catecholamine synthesis in pheochromocytoma and paraganglioma
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DOI: 10.1002/cncr.35426
Abstract: Pheochromocytomas and paragangliomas (PPGLs) typically secrete catecholamines and their metabolites (metanephrines [MN] and normetanephrine [NMN]). Catecholamines are synthesized by several enzymes: phenylalanine hydroxylase (encoded by PAH), tyrosine hydroxylase (TH), aromatic L‐amino acid decarboxylase (DDC), dopamine… read more here.
Keywords: epigenetic regulation; role epigenetic; catecholamine synthesis; regulation catecholamine ... See more keywords
Inhibitory Effects of Vandetanib on Catecholamine Synthesis in Rat Pheochromocytoma PC12 Cells
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DOI: 10.3390/ijms26146927
Abstract: Gain-of-function gene alterations in rearranged during transfection (RET), a receptor tyrosine kinase, are observed in both sporadic and hereditary medullary thyroid cancers (MTCs) and pheochromocytomas and paragangliomas (PPGLs). Several tyrosine kinase inhibitors (TKIs) that target… read more here.
Keywords: pc12 cells; catecholamine synthesis; synthesis; rat pheochromocytoma ... See more keywords