Cell-cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β-catenin.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14341
Abstract: E-cadherin (CDH1) is involved in maintaining cell-cell adhesions in embryonic stem cells (ESCs). However, its function in the context of cell fate decisions is largely unknown. Using mouse ESCs (mESCs), we demonstrate that E-cadherin and… read more here.
Keywords: catenin; cell adhesions; cell; cell cell ... See more keywords
DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12089
Abstract: Gastric cancer (GC) represents the fourth most common malignant neoplasm and the second leading cause of cancer death. Despite therapeutic advances in recent decades, the clinical outcome remains dismal owing to the fact that most… read more here.
Keywords: ddah1; invasion; gastric cancer; catenin ... See more keywords
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13201
Abstract: Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415,… read more here.
Keywords: wnt catenin; trip13; dcz0415; crc ... See more keywords
GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12769
Abstract: Glutathione S‐transferase Zeta 1‐1 (GSTZ1‐1), an enzyme involved in the catabolism of phenylalanine and the detoxification of xenobiotics, plays a tumour suppressor role in hepatocellular carcinoma (HCC), but the underlying mechanism remains largely unknown. Here,… read more here.
Keywords: hepatocellular carcinoma; gstz1; analysis; catenin ... See more keywords
Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13236
Abstract: Tumor metastasis remains a major challenge for patients with breast cancer. Aberrant epigenetic factor lysine‐specific demethylase 6B (KDM6B) has been associated with tumor progression. Here, we show that KDM6B is significantly down‐regulated in human breast… read more here.
Keywords: catenin; breast cancer; metastasis; cancer ... See more keywords
Exosomal circ-AHCY promotes glioblastoma cell growth via Wnt/β-catenin signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51743
Abstract: BACKGROUND Glioblastoma (GBM) is the most aggressive brain tumor. Reportedly, circular RNAs (circRNAs) participate in regulation of the development and progression of diverse cancers, including GBM. METHODS Dysregulated circRNAs in GBM tissues were screened out… read more here.
Keywords: circ ahcy; circ; catenin; cell growth ... See more keywords
Blockade of Nuclear β‐Catenin Signaling via Direct Targeting of RanBP3 with NU2058 Induces Cell Senescence to Suppress Colorectal Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202528
Abstract: Colorectal cancer (CRC) is one of the most common malignant tumors in the world, with high prevalence and low 5‐year survival. Most of the CRC patients show excessive activation of the Wnt/β‐catenin pathway which is… read more here.
Keywords: nu2058; catenin; ranbp3; crc ... See more keywords
SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9‐Mediated GSK3β/β‐Catenin Signaling
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202203573
Abstract: Recurrence is a challenge to survival after the initial treatment of esophageal squamous cell carcinoma (ESCC). But, its mechanism remains elusive and there are currently no biomarkers to predict postoperative recurrence. Here, the possibility of… read more here.
Keywords: myh9; recurrence; postoperative recurrence; catenin ... See more keywords
MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308417
Abstract: O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ). However, the biological importance of MGMT and the… read more here.
Keywords: men1; catenin; mgmt; expression ... See more keywords
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202503223
Abstract: Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC… read more here.
Keywords: cancer; catenin; cdk5; limk1 ... See more keywords
Discovery of a novel 2,4‐thiazolidinedione derivative as dual inhibitor of β‐catenin/TCF4 interaction and tubulin polymerization in colon cancer cells
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400796
Abstract: Hyperactivation of the Wnt/β‐catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Based on a previously reported lead compound, iCRT14, a series of 2,4‐thiazolidinedione derivatives were designed, synthesized, and… read more here.
Keywords: cancer; cancer cells; catenin; catenin tcf4 ... See more keywords