Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation
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DOI: 10.1038/s41598-020-74080-2
Abstract: The tumor suppressor adenomatous polyposis coli (APC) is frequently mutated in colorectal cancers. APC and Axin are core components of a destruction complex that scaffolds GSK3β and CK1 to earmark β-catenin for proteosomal degradation. Disruption… read more here.
Keywords: degradation; tumor suppressor; catenin; catenin degradation ... See more keywords
The natural agent rhein induces β‐catenin degradation and tumour growth arrest
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DOI: 10.1111/jcmm.13346
Abstract: The natural agent rhein is an ananthraquinone derivative of rhubarb, which has anticancer effects. To determine the mechanisms underlying the anticancer effects of rhein, we detected the effect of rhein on several oncoproteins. Here, we… read more here.
Keywords: catenin; rhein induces; rhein; growth ... See more keywords
Dalbinol, a rotenoid from Amorpha fruticosa L., exerts anti-proliferative activity by facilitating β-catenin degradation in hepatocellular carcinoma cells
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DOI: 10.18632/oncotarget.17766
Abstract: Hepatocellular carcinoma (HCC) is a highly malignant tumor, and the main cause of treatment failure is malignant proliferation. Aberrations in Wnt/β-catenin signaling are associated with HCC development. Despite the improvements in overall survival made over… read more here.
Keywords: hepatocellular carcinoma; dalbinol; hcc; catenin ... See more keywords