APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
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DOI: 10.1038/s41598-020-59899-z
Abstract: Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli ( APC ). APC is an essential component of a… read more here.
Keywords: destruction complex; destruction; wnt induced; catenin destruction ... See more keywords
Molecular regulation and pharmacological targeting of the β‐catenin destruction complex
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DOI: 10.1111/bph.13922
Abstract: The β‐catenin destruction complex is a dynamic cytosolic multiprotein assembly that provides a key node in Wnt signalling regulation. The core components of the destruction complex comprise the scaffold proteins axin and adenomatous polyposis coli… read more here.
Keywords: molecular regulation; destruction; catenin destruction; destruction complex ... See more keywords
Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Medicina oral, patologia oral y cirugia bucal"
DOI: 10.4317/medoral.24528
Abstract: BACKGROUND Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant… read more here.
Keywords: oral dysplasia; catenin destruction; components catenin; destruction complex ... See more keywords