β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models
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DOI: 10.1158/1535-7163.mct-17-0605
Abstract: Colorectal carcinomas harbor well-defined genetic abnormalities, including aberrant activation of Wnt/β-catenin and MAPK pathways, often simultaneously. Although the MAPK pathway can be targeted using potent small-molecule drugs, including BRAF and MEK inhibitors, β-catenin inhibition has… read more here.
Keywords: catenin mrna; inhibition; synergistic efficacy; cancer ... See more keywords