GSTZ1‐1 downregulates Wnt/β‐catenin signalling in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12769
Abstract: Glutathione S‐transferase Zeta 1‐1 (GSTZ1‐1), an enzyme involved in the catabolism of phenylalanine and the detoxification of xenobiotics, plays a tumour suppressor role in hepatocellular carcinoma (HCC), but the underlying mechanism remains largely unknown. Here,… read more here.
Keywords: hepatocellular carcinoma; gstz1; analysis; catenin ... See more keywords
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.020
Abstract: Phenanthridine derivativeHLY78 has previously been identified as the first Wnt/β-catenin signalling pathway agonist that targets the DAX domain of axin. However, due to the relatively weak activation on the Wnt/β-catenin signalling pathway, HLY78 is insufficient… read more here.
Keywords: catenin signalling; signalling pathway; structure activity; activity ... See more keywords
Autophagy induction impairs Wnt/β-catenin signalling through β-catenin relocalisation in glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.10.017
Abstract: Autophagy is an evolutionary conserved process mediating lysosomal degradation of cytoplasmic material. Its involvement in cancer progression is highly controversial, due to its dual role in both limiting tumoural transformation and in protecting established tumoral… read more here.
Keywords: catenin relocalisation; catenin; catenin signalling; autophagy induction ... See more keywords
AGR3 promotes the stemness of colorectal cancer via modulating Wnt/β-catenin signalling.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109419
Abstract: Cancer cells with stem cell properties have been acknowledged to be responsible for cancer initiation and progression. Wnt/β-catenin signalling is a major signal pathway promoting the stemness of cancer cells. Anterior gradient 3 (AGR3), a… read more here.
Keywords: catenin; colorectal cancer; catenin signalling; crc ... See more keywords
Wnt/B-catenin signalling facilitates cell fate decision making in the early mouse embryo
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.453
Abstract: to be faithfully maintained for normal homeostatic tissue functions. How cells integrate developmental and signalling-dependent instructions to acquire or alter transcriptional states remains a fundamental question in developmental biology. Polycomb and Trithorax group members act… read more here.
Keywords: signalling facilitates; chromatin; signalling pathways; catenin signalling ... See more keywords
Galectin-3 favours tumour metastasis via the activation of β-catenin signalling in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-1022-4
Abstract: Background High probability of metastasis limited the long-term survival of patients with hepatocellular carcinoma (HCC). Our previous study revealed that Galectin-3 was closely associated with poor prognosis in HCC patients. Methods The effects of Galectin-3… read more here.
Keywords: hepatocellular carcinoma; hcc; tumour metastasis; catenin ... See more keywords
Molecular signature of an ancient organizer regulated by Wnt/β-catenin signalling during primary body axis patterning in Hydra
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DOI: 10.1038/s42003-019-0680-3
Abstract: Wnt/β-catenin signalling has been shown to play a critical role during head organizer formation in Hydra. Here, we characterized the Wnt signalling regulatory network involved in formation of the head organizer. We found that Wnt… read more here.
Keywords: catenin; catenin signalling; body axis; wnt catenin ... See more keywords
Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20191043
Abstract: BACKGROUND Mounting evidence has displayed critical roles of circular RNAs (circRNAs) in multiple cancers. The underlying mechanisms by which circFGD4 contributed to gastric cancer (GC) are still unclear. METHODS The levels and clinical values of… read more here.
Keywords: catenin signalling; gastric cancer; mir 532; apc catenin ... See more keywords
The dynamic expression of canonical Wnt/β-catenin signalling pathway in the pathologic process of experimental autoimmune neuritis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1725511
Abstract: Abstract Background: Guillain-Barré syndrome (GBS), an autoimmune disease and an acute inflammation disorder, is currently the most frequent cause of acute flaccid paralysis worldwide. EAN, an animal model of GBS, is a CD4+ T cell-mediated… read more here.
Keywords: catenin; canonical wnt; group; catenin signalling ... See more keywords
P5000Wnt/b-catenin signalling drives angiotensin II induced cardiac fibrosis via WISP-1
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0178
Abstract: Myocardial infarction (MI) and hypertension lead to myocardial injury, which induces negative remodelling and cardiac fibrosis. Cardiac fibrosis, which involves inflammatory cell infiltration and myofibroblast activation, causes worldwide mortality and morbidity. In response to MI… read more here.
Keywords: collagen; fibrosis; cardiac fibrosis; catenin signalling ... See more keywords
MicroRNA‐520e targets AEG‐1 to suppress the proliferation and invasion of colorectal cancer cells through Wnt/GSK‐3β/β‐catenin signalling
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13185
Abstract: MicroRNA‐520e (miR‐520e) is increasingly being recognized as a cancer‐related miRNA in multiple cancer types; however, little is known about its role in colorectal cancer. In this study, we determined the specific role of miR‐520e in… read more here.
Keywords: cancer; mir 520e; colorectal cancer; catenin signalling ... See more keywords