KSHV vPK inhibits Wnt signaling via preventing interactions between β-catenin and TCF4.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.089
Abstract: Viral factors interact with host cellular proteins, leading to dysregulation of signaling pathways. The Wnt pathway is known to participate in embryonic development and oncogenesis under dysregulation conditions. A downstream factor of the Wnt signaling… read more here.
Keywords: inhibits wnt; wnt signaling; catenin tcf4; signaling pathway ... See more keywords
A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.09.029
Abstract: Colorectal cancer is associated with aberrant activation of the Wnt pathway. β-Catenin plays essential roles in the Wnt pathway by interacting with T-cell factor 4 (TCF4) to transcribe oncogenes. We synthesized a small molecule, referred… read more here.
Keywords: catenin tcf4; small molecule; catenin; colorectal cancer ... See more keywords
A small-molecule LF3 abrogates β-catenin/TCF4-mediated suppression of NaV1.5 expression in HL-1 cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.08.007
Abstract: Increased nuclear β-catenin interacting with T-cell factor 4 (TCF4) affects the expression of target genes including SCN5A in ischemic heart disease, which is characterized by frequent ventricular tachycardia/fibrillation. A complex of β-catenin and TCF4 inhibits… read more here.
Keywords: catenin tcf4; activity; nav1 expression; tcf4 ... See more keywords
FOXM 1 induces Vasculogenic mimicry in esophageal cancer through β-catenin /Tcf4 signaling
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic Pathology"
DOI: 10.1186/s13000-020-00929-9
Abstract: Objective To investigate the role of FOXM1, β-catenin and TCF4 in esophageal cancer (EC) and their relationship to VM (Vasculogenic Mimicry). Methods CCK-8 were performed to examine EC cell proliferation in FOXM1 silenced cells. EC… read more here.
Keywords: esophageal cancer; catenin; vasculogenic mimicry; catenin tcf4 ... See more keywords