Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202100694
Abstract: A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened in vitro for inhibition of deoxyribonuclease I (DNase I). Compounds 22, 8 and 7 are among the most potent synthetic non‐peptide DNase I… read more here.
Keywords: deoxyribonuclease; dnase; cathepsin; repurposing hydroxyquinoline ... See more keywords
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1674
Abstract: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine… read more here.
Keywords: role cathepsin; cathepsin; heart failure;
An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice
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DOI: 10.1002/jbmr.3227
Abstract: The potent cathepsin K (CatK) inhibitor, Tanshinone IIA sulfonic sodium (T06), was tested for its in vitro and in vivo antiresorptive activities. T06 binds in an ectosteric site of CatK remote from its active site… read more here.
Keywords: inhibitor; bone resorption; cathepsin; site ... See more keywords
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors
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DOI: 10.1002/psc.3014
Abstract: Cathepsin D (Cath D) is overexpressed and secreted in a number of solid tumors and involved in the progress of tumor invasion, proliferation, metastasis, and apoptosis. Inhibition of Cath D is regarded as an attractive… read more here.
Keywords: cyanobacterial peptides; cathepsin; cath; peptides prototype ... See more keywords
FITC characterization of a cathepsin B‐responsive nanoprobe for report of differentiation of HL60 cells into macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Peptide Science"
DOI: 10.1002/psc.3371
Abstract: A cathepsin B (Cat B)‐responsive optical nanoprobe is designed and prepared for report of HL60 differentiation into macrophage. A peptide sequence FRFK is linked to fluorescein (FITC) via the distant amino group of its lysine… read more here.
Keywords: differentiation; report; hl60 cells; cathepsin ... See more keywords
Multiplex Cathepsin Zymography to Detect Amounts of Active Cathepsins K, L, S, and V.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7111-4_23
Abstract: Cysteine cathepsins are powerful proteases that can degrade other proteins, among which are the extracellular matrix proteins collagen and elastin. Multiplex cathepsin zymography is an assay that can quantify the amount of active cathepsins in… read more here.
Keywords: active cathepsins; cathepsin zymography; amounts active; cathepsin ... See more keywords
VPS52 induces apoptosis via cathepsin D in gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1572-y
Abstract: Vacuolar protein sorting (VPS) genes encode a class of proteins involved in vesicular trafficking. Growing evidence suggests that VPS proteins play roles in tumor biology. Vacuolar protein sorting 52 (VPS52) is involved in retrograde transport… read more here.
Keywords: gastric cancer; cathepsin; cancer cells; vps52 ... See more keywords
Development of a New Immunoassay for Human Cathepsin K-Generated Periostin Fragments as a Serum Biomarker for Cortical Bone
Sign Up to like & getrecommendations! Published in 2017 at "Calcified Tissue International"
DOI: 10.1007/s00223-017-0302-3
Abstract: Periostin is a matricellular protein mainly expressed by periosteal cells and osteocytes in bone, but is also present in several other tissues. Available immunoassays use antibodies of unclear specificity. The aim of the study was… read more here.
Keywords: generated periostin; cortical bone; periostin fragments; cathepsin ... See more keywords
Is the genetic variability of Cathepsin B important in the pathogenesis of Blastocystis spp.?
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DOI: 10.1007/s00436-018-6103-4
Abstract: The potential role of Blastocystis as a pathogen is controversial because it is found in both symptomatic and asymptomatic carriers. Since Cathepsin B has been identified as a main virulence factor that contributes to the… read more here.
Keywords: blastocystis; cases controls; cathepsin; genetic variability ... See more keywords
Adjuvant-free schistosome cathepsin L3 is an efficacious schistosomiasis vaccine–comment on Huang et al.: Characteristics and function of cathepsin L3 from Schistosoma japonicum
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06737-w
Abstract: Dear Editor: We read with interest the article by Huang et al. (2020) reporting on the Schistosoma japonicum cathepsin L3 gene successful cloning and expression, accurate protein distribution in the different parasites stages, especially the… read more here.
Keywords: schistosome; schistosoma japonicum; huang; cathepsin ... See more keywords
Update on hereditary, autosomal dominant cathepsin-A-related arteriopathy with strokes and leukoencephalopathy (CARASAL)
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-019-01158-8
Abstract: Cathepsin-A-related arteriopathy with strokes and leukoencephalopathy (CARASAL) is an acronym that describes an ultra-rare, hereditary, cerebral small vessel disease. The aim is to summarize current knowledge and recent findings concerning phenotype, genotype, pathogenesis, diagnoses, and… read more here.
Keywords: carasal; cathepsin; strokes leukoencephalopathy; related arteriopathy ... See more keywords