Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin‐K Activity Detection, Revealing Nuclear Activity (Adv. Sci. 38/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470230
Abstract: Activity‐Based Probes The cover highlights a novel chemical probe that binds a protease, cathepsin K (K), a key player in bone resorption. The probe detects active K in the cell by producing a fluorescent signal.… read more here.
Keywords: development application; application reversible; activity; cathepsin activity ... See more keywords
Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors
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DOI: 10.1002/cmdc.202100694
Abstract: A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened in vitro for inhibition of deoxyribonuclease I (DNase I). Compounds 22, 8 and 7 are among the most potent synthetic non‐peptide DNase I… read more here.
Keywords: deoxyribonuclease; dnase; cathepsin; repurposing hydroxyquinoline ... See more keywords
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach
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DOI: 10.1002/ejhf.1674
Abstract: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine… read more here.
Keywords: role cathepsin; cathepsin; heart failure;
Toward Novel Trifluoromethylated Peptidomimetics: A Case Study of Cathepsin C Inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500773
Abstract: Herein, both synthetic and theoretical results related to the development of amino acid analogues containing a CF 3 ‐olefinic moiety and their evaluation as potential inhibitors of Cathepsin C are presented. The key synthetic steps… read more here.
Keywords: toward novel; trifluoromethylated peptidomimetics; novel trifluoromethylated; peptidomimetics case ... See more keywords
An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice
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DOI: 10.1002/jbmr.3227
Abstract: The potent cathepsin K (CatK) inhibitor, Tanshinone IIA sulfonic sodium (T06), was tested for its in vitro and in vivo antiresorptive activities. T06 binds in an ectosteric site of CatK remote from its active site… read more here.
Keywords: inhibitor; bone resorption; cathepsin; site ... See more keywords
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors
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DOI: 10.1002/psc.3014
Abstract: Cathepsin D (Cath D) is overexpressed and secreted in a number of solid tumors and involved in the progress of tumor invasion, proliferation, metastasis, and apoptosis. Inhibition of Cath D is regarded as an attractive… read more here.
Keywords: cyanobacterial peptides; cathepsin; cath; peptides prototype ... See more keywords
FITC characterization of a cathepsin B‐responsive nanoprobe for report of differentiation of HL60 cells into macrophages
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DOI: 10.1002/psc.3371
Abstract: A cathepsin B (Cat B)‐responsive optical nanoprobe is designed and prepared for report of HL60 differentiation into macrophage. A peptide sequence FRFK is linked to fluorescein (FITC) via the distant amino group of its lysine… read more here.
Keywords: differentiation; report; hl60 cells; cathepsin ... See more keywords
Multiplex Cathepsin Zymography to Detect Amounts of Active Cathepsins K, L, S, and V.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7111-4_23
Abstract: Cysteine cathepsins are powerful proteases that can degrade other proteins, among which are the extracellular matrix proteins collagen and elastin. Multiplex cathepsin zymography is an assay that can quantify the amount of active cathepsins in… read more here.
Keywords: active cathepsins; cathepsin zymography; amounts active; cathepsin ... See more keywords
VPS52 induces apoptosis via cathepsin D in gastric cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1572-y
Abstract: Vacuolar protein sorting (VPS) genes encode a class of proteins involved in vesicular trafficking. Growing evidence suggests that VPS proteins play roles in tumor biology. Vacuolar protein sorting 52 (VPS52) is involved in retrograde transport… read more here.
Keywords: gastric cancer; cathepsin; cancer cells; vps52 ... See more keywords
Development of a New Immunoassay for Human Cathepsin K-Generated Periostin Fragments as a Serum Biomarker for Cortical Bone
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DOI: 10.1007/s00223-017-0302-3
Abstract: Periostin is a matricellular protein mainly expressed by periosteal cells and osteocytes in bone, but is also present in several other tissues. Available immunoassays use antibodies of unclear specificity. The aim of the study was… read more here.
Keywords: generated periostin; cortical bone; periostin fragments; cathepsin ... See more keywords
Improved recombinant expression of soluble cathepsin B and L in Escherichia coli
Sign Up to like & getrecommendations! Published in 2024 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-024-13374-1
Abstract: Cysteine cathepsins such as cathepsin B and L play an important role in numerous diseases like acute pancreatitis or SARS-CoV-2 and therefore have high potential for the development of new therapeutics. To be able to… read more here.
Keywords: recombinant expression; coli; expression; soluble cathepsin ... See more keywords