Cathepsin B and L inhibitors: a patent review (2010 - present)
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1272572
Abstract: ABSTRACT Introduction: Cathepsins play an important role in protein degradation and processing. Aberrant cathepsin B or L is closely associated with many serious diseases such as cancer, osteoporosis and autoimmune disorders. Therefore, development of potent… read more here.
Keywords: patent review; cathepsin; inhibitors patent; 2010 present ... See more keywords
Caspase-1 and Cathepsin B Inhibitors from Marine Invertebrates, Aiming at a Reduction in Neuroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20100614
Abstract: Neuroinflammation is a condition associated with several types of dementia, such as Alzheimer’s disease (AD), mainly caused by an inflammatory response to amyloid peptides that induce microglial activation, with subsequent cytokine release. Neuronal caspase-1 from… read more here.
Keywords: cathepsin inhibitors; neuroinflammation; caspase cathepsin; marine invertebrates ... See more keywords
Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-N-Oxide Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24132348
Abstract: Infections caused by Fasciola species are widely distributed in cattle and sheep causing significant economic losses, and are emerging as human zoonosis with increasing reports of human cases, especially in children in endemic areas. The… read more here.
Keywords: quinoxaline oxide; activity liver; oxide derivatives; inhibitors activity ... See more keywords
Design, Synthesis and In-Silico Studies of Novel Chalcones as Anti-Prostate Cancer and Cathepsin B Inhibitors -
Sign Up to like & getrecommendations! Published in 2017 at "journal of applied pharmaceutical science"
DOI: 10.7324/japs.2017.70702
Abstract: The high mortality rate in prostate cancer patients could be mainly attributed to the invasiveness and metastasis of advanced prostate cancer. Cathepsin B, a lysosomal cysteine, that proved to play a significant role in the… read more here.
Keywords: prostate cancer; cathepsin; cancer cathepsin; anti prostate ... See more keywords