Cathepsin B promotes Aβ proteotoxicity by modulating aging regulating mechanisms
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DOI: 10.1038/s41467-024-52540-x
Abstract: While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients.… read more here.
Keywords: cathepsin promotes; promotes proteotoxicity; aging regulating; proteotoxicity ... See more keywords