The cation channel TRPM8 influences the differentiation and function of human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1hi0421-181r
Abstract: Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under the influence of their microenvironment and hardwired commitment. We found that inhibition of TRPM8 in human blood CD14+ monocytes during a… read more here.
Keywords: cation channel; function; trpm8; trpm8 influences ... See more keywords
Differences among muscarinic agonists in M1 receptor‐mediated nonselective cation channel activation and TASK1 channel inhibition in adrenal medullary cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.11.021
Abstract: ABSTRACT Muscarinic receptor stimulation induces depolarizing inward currents and catecholamine secretion in adrenal medullary (AM) cells from various mammals. In guinea‐pig AM cells muscarine and oxotremorine at concentrations ≤ 1 &mgr;M produce activation of nonselective… read more here.
Keywords: cation channel; nonselective cation; channel; activation ... See more keywords
Structures of the Calcium-activated Non-Selective Cation Channel TRPM4
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24997
Abstract: TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) -modulated, non-selective cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) channels. Here we present the electron cryo-microscopy structures of the mouse TRPM4 channel with… read more here.
Keywords: trpm4; cation channel; channel; non selective ... See more keywords
Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1008626
Abstract: Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors. However, the mechanism by which plasmalogens modulate receptor function… read more here.
Keywords: cation channel; potential cation; receptor potential; receptor ... See more keywords
Transient Receptor Potential Cation Channel Subfamily V Member 1 Expression Promotes Chemoresistance in Non-Small-Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.773654
Abstract: Approximately 85% of lung cancer cases are non-small-cell lung cancer (NSCLC). Chemoresistance is a leading cause of chemotherapy failure in NSCLC treatment. Transient receptor potential cation channel subfamily V, member 1 (TRPV1), a non-selective cation… read more here.
Keywords: lung cancer; cell; cation channel; expression ... See more keywords
Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11050397
Abstract: The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions. TRPM2 is a homotetrameric Ca2+-permeable… read more here.
Keywords: cation channel; receptor potential; potential melastatin; channel ... See more keywords