The cation channel TRPM8 influences the differentiation and function of human monocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1hi0421-181r
Abstract: Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under the influence of their microenvironment and hardwired commitment. We found that inhibition of TRPM8 in human blood CD14+ monocytes during a… read more here.
Keywords: cation channel; function; trpm8; trpm8 influences ... See more keywords
Differences among muscarinic agonists in M1 receptor‐mediated nonselective cation channel activation and TASK1 channel inhibition in adrenal medullary cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.11.021
Abstract: ABSTRACT Muscarinic receptor stimulation induces depolarizing inward currents and catecholamine secretion in adrenal medullary (AM) cells from various mammals. In guinea‐pig AM cells muscarine and oxotremorine at concentrations ≤ 1 &mgr;M produce activation of nonselective… read more here.
Keywords: cation channel; nonselective cation; channel; activation ... See more keywords
Structures of the Calcium-activated Non-Selective Cation Channel TRPM4
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24997
Abstract: TRPM4 is a calcium-activated, phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) -modulated, non-selective cation channel that belongs to the family of melastatin-related transient receptor potential (TRPM) channels. Here we present the electron cryo-microscopy structures of the mouse TRPM4 channel with… read more here.
Keywords: trpm4; cation channel; channel; non selective ... See more keywords
P-060 Sperm cation channel dysfunction as a hidden cause of infertility and in vitro fertilisation failure in a couple
Sign Up to like & getrecommendations! Published in 2025 at "Human Reproduction"
DOI: 10.1093/humrep/deaf097.369
Abstract: What is the incidence of sperm cation channel (CatSper) dysfunction in a population of idiopathic infertility patients? CatSper dysfunction was found in 1/27 (3.7%, 95% CI: 0.0-11.1%) unexplained-infertile cases. Dysfunction test result was confirmed by… read more here.
Keywords: infertility; dysfunction; test; sperm cation ... See more keywords
Transient receptor potential melastatin 7 cation channel, magnesium and cell metabolism in vascular health and disease
Sign Up to like & getrecommendations! Published in 2025 at "Acta Physiologica"
DOI: 10.1111/apha.14282
Abstract: Preserving the balance of metabolic processes in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), is crucial for optimal vascular function and integrity. ECs are metabolically active and depend on aerobic glycolysis to efficiently… read more here.
Keywords: potential melastatin; receptor potential; metabolism; cation ... See more keywords
Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1008626
Abstract: Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors. However, the mechanism by which plasmalogens modulate receptor function… read more here.
Keywords: cation channel; potential cation; receptor potential; receptor ... See more keywords
Transient Receptor Potential Cation Channel Subfamily V Member 1 Expression Promotes Chemoresistance in Non-Small-Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.773654
Abstract: Approximately 85% of lung cancer cases are non-small-cell lung cancer (NSCLC). Chemoresistance is a leading cause of chemotherapy failure in NSCLC treatment. Transient receptor potential cation channel subfamily V, member 1 (TRPV1), a non-selective cation… read more here.
Keywords: lung cancer; cell; cation channel; expression ... See more keywords
Mechanosensitive Cation Channel Piezo1 Is Involved in Renal Fibrosis Induction
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25031718
Abstract: Renal fibrosis, the result of different pathological processes, impairs kidney function and architecture, and usually leads to renal failure development. Piezo1 is a mechanosensitive cation channel highly expressed in kidneys. Activation of Piezo1 by mechanical… read more here.
Keywords: fibrosis; renal fibrosis; mechanosensitive cation; cation channel ... See more keywords
Two Decades of Evolution of Our Understanding of the Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11050397
Abstract: The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions. TRPM2 is a homotetrameric Ca2+-permeable… read more here.
Keywords: cation channel; receptor potential; potential melastatin; channel ... See more keywords