Structure and mechanism of the cation–chloride cotransporter NKCC1
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1438-2
Abstract: Cation–chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume, controlling ion absorption and secretion across epithelia, and maintaining intracellular chloride homeostasis.… read more here.
Keywords: cotransporter nkcc1; cation chloride; ion; chloride ... See more keywords
The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01750-w
Abstract: NKCC and KCC transporters mediate coupled transport of Na + +K + +Cl − and K + +Cl − across the plasma membrane, thus regulating cell Cl − concentration and cell volume and playing critical… read more here.
Keywords: structural basis; microscopy; transport; cation chloride ... See more keywords
Structure of the human cation–chloride cotransport KCC1 in an outward-open state
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109083119
Abstract: Significance Cation–chloride cotransporters (CCCs) shuttle Na+, K+, and Cl− across membranes. However, it remains unclear how CCCs alternate between transport states so they can load ions from one side of a membrane for release into… read more here.
Keywords: structure human; human cation; cation; cation chloride ... See more keywords
Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179968
Abstract: Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl−). They are divided into K+-Cl− outward transporters (KCCs), the Na+-K+-Cl− (NKCCs) and Na+-Cl− (NCCs)… read more here.
Keywords: cation chloride; cotransporter; hydra vulgaris; chloride cotransporter ... See more keywords
Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.813441
Abstract: The construction of the brain relies on a series of well-defined genetically and experience- or activity -dependent mechanisms which allow to adapt to the external environment. Disruption of these processes leads to neurological and psychiatric… read more here.
Keywords: establish proper; cation chloride; cation; chloride transporters ... See more keywords
Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.817013
Abstract: Intracellular chloride (Cl–) levels in mature neurons must be tightly regulated for the maintenance of fast synaptic inhibition. In the mature central nervous system (CNS), synaptic inhibition is primarily mediated by gamma-amino butyric acid (GABA),… read more here.
Keywords: huntington disease; chloride; cation chloride; brain ... See more keywords
Heterologous Expression of Aedes aegypti Cation Chloride Cotransporter 2 (aeCCC2) in Xenopus laevis Oocytes Induces an Enigmatic Na+/Li+ Conductance
Sign Up to like & getrecommendations! Published in 2019 at "Insects"
DOI: 10.3390/insects10030071
Abstract: The yellow fever mosquito Aedes aegypti possesses three genes encoding putative Na+-coupled cation chloride cotransporters (CCCs): aeNKCC1, aeCCC2, and aeCCC3. To date, none of the aeCCCs have been functionally characterized. Here we expressed aeCCC2 heterologously… read more here.
Keywords: aedes aegypti; cation; aeccc2; cation chloride ... See more keywords
Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031344
Abstract: Neurological diseases including Alzheimer’s, Huntington’s disease, Parkinson’s disease, Down syndrome and epilepsy, and neuropsychiatric disorders such as schizophrenia, are conditions that affect not only individuals but societies on a global scale. Current therapies offer a… read more here.
Keywords: cation chloride; chloride cotransporters; cotransporters kcc2; neuropsychiatric disorders ... See more keywords