Manipulation of a cation-π sandwich reveals conformational flexibility in phenylalanine hydroxylase.
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DOI: 10.1016/j.biochi.2020.11.011
Abstract: Phenylalanine hydroxylase (PAH) is an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism. Wild type (WT) PAH equilibrates among resting-state (RS-PAH) and… read more here.
Keywords: pah; cation sandwich; phe; phenylalanine hydroxylase ... See more keywords