Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells
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DOI: 10.1007/s11064-017-2350-5
Abstract: Brain immune cells, i.e., microglia, play an important role in the maintenance of brain homeostasis, whereas chronic overactivation of microglia is involved in the development of various neurodegenerative disorders. Therefore, the regulation of microglial activation… read more here.
Keywords: cation transporter; transporter octn1; organic cation; carnitine organic ... See more keywords
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical research"
DOI: 10.1007/s11095-022-03171-8
Abstract: INTRODUCTION The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudied as a determinant of pharmacokinetics and pharmacodynamics,… read more here.
Keywords: drug; prescription; organic cation; cation transporter ... See more keywords
Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105959
Abstract: Tripterygium wilfordii Hook. F. (TwHF), a traditional Chinese Medicine, is effective in treating rheumatoid arthritis (RA), but its severe nephrotoxicity limits its extensive application. The nephrotoxic mechanism of Triptolide (TP), the main pharmacological and toxic… read more here.
Keywords: cation transporter; rheumatoid arthritis; arthritis; organic cation ... See more keywords
Selective Inhibition of Organic Cation Transporter 1 by Benzoylpaeoniflorin Attenuates Hepatic Lipid Accumulation through AMPK Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00927
Abstract: Organic cation transporter 1 (OCT1) is a liver-specific transporter and plays an essential role in drug disposition and hepatic lipid metabolism. Therefore, inhibition of OCT1 may not only lead to drug-drug interactions but also represent… read more here.
Keywords: hepatic lipid; transporter; lipid accumulation; cation transporter ... See more keywords
Downregulation of organic cation transporter 1 and breast cancer resistance protein with the induction of Pregnane X receptor in rat kidney impaired by doxorubicin.
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DOI: 10.1691/ph.2019.9703
Abstract: Transporters expressed in the kidney play an important role in the excretion of endogenous substances and chemical drugs. The Pregnane X receptor (PXR) has been reported to be involved in regulating the expression of numerous… read more here.
Keywords: cation transporter; breast cancer; expression; pregnane receptor ... See more keywords
Atypical Substrates of the Organic Cation Transporter 1
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111664
Abstract: The human organic cation transporter 1 (OCT1) is expressed in the liver and mediates hepatocellular uptake of organic cations. However, some studies have indicated that OCT1 could transport neutral or even anionic substrates. This capability… read more here.
Keywords: atypical substrates; organic cation; cation transporter; oct1 ... See more keywords