Genetic and Epigenetic Regulation of Organic Cation Transporters.
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DOI: 10.1007/164_2021_450
Abstract: Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 are the subject of intensive research because they mediate the transport of many clinically-relevant drugs such as the antidiabetic agent metformin, the opioid tramadol,… read more here.
Keywords: epigenetic regulation; organic cation; oct2 oct3; cation transporters ... See more keywords
Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice.
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DOI: 10.1007/s11095-021-03002-2
Abstract: PURPOSE To investigate the role of cation transporters (OCTs, MATEs) in the renal and hepatic disposition of the radiolabeled antiemetic drug [11C]metoclopramide in mice with PET. METHODS PET was performed in wild-type mice after administration… read more here.
Keywords: 11c metoclopramide; metoclopramide mice; metoclopramide; cation transporters ... See more keywords
Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2
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DOI: 10.1021/acs.jmedchem.5c00056
Abstract: The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug–drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely understood.… read more here.
Keywords: cation transporters; overlap; mate1 mate2k; oct1 oct2 ... See more keywords
Health risks of cocaine adulteration: local anesthetics as modulators of monoamine and organic cation transporters
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1699035
Abstract: Introduction Local anesthetics (LAs) are frequently used as adulterants in cocaine sold on the illicit market, sometimes in higher quantities than cocaine itself. These agents can mimic cocaine’s anesthetic effect, masking the products reduced purity.… read more here.
Keywords: organic cation; cation transporters; health risks; local anesthetics ... See more keywords
Cation Transporters of Candida albicans—New Targets to Fight Candidiasis?
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DOI: 10.3390/biom11040584
Abstract: Candidiasis is the wide-spread fungal infection caused by numerous strains of yeast, with the prevalence of Candida albicans. The current treatment of candidiasis is becoming rather ineffective and costly owing to the emergence of resistant… read more here.
Keywords: candidiasis; cation transporters; candida albicans; new targets ... See more keywords
Organic Cation Transporters (OCTs) in EpiAirway™, a Cellular Model of Normal Human Bronchial Epithelium
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DOI: 10.3390/biomedicines8050127
Abstract: Organic cation transporters (OCTs) and novel organic cation transporters (OCTNs) are responsible for drug delivery in the intestine and kidney; in the lung, OCTs mediate inhaled drugs’ transport, although their physiological role in airways remains… read more here.
Keywords: model normal; octs epiairway; transporters octs; cation transporters ... See more keywords
Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1–3 and Human Plasma Membrane Monoamine Transporter
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312995
Abstract: Many psychoactive compounds have been shown to primarily interact with high-affinity and low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; norepinephrine transporter), dopamine (DAT; dopamine transporter) and serotonin (SERT; serotonin transporter). Previous studies… read more here.
Keywords: cation transporters; organic cation; transporter; monoamine ... See more keywords
Interaction of Masitinib with Organic Cation Transporters
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214189
Abstract: Tyrosine kinase inhibitors (TKI) such as Masitinib were reported to be useful as therapeutic options in malignant disorders and nonmalignant diseases, like coronavirus disease 2019 (COVID-19). Most kinases must be translocated into targeted cells by… read more here.
Keywords: cation transporters; organic cation; masitinib organic; interaction masitinib ... See more keywords