Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt01146f
Abstract: Although relevant from the clinical point of view, radiotracers targeting cationic amino acid transporters are relatively unexplored and, in particular, no metal-based radiotracers are known. The rare examples of complexes recognized by amino acid transporters,… read more here.
Keywords: acid transporters; amino; amino acid; cationic amino ... See more keywords
The effects of maternal nutrition during the first 50 days of gestation on the location and abundance of hexose and cationic amino acid transporters in beef heifer utero-placental tissues.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of animal science"
DOI: 10.1093/jas/skaa386
Abstract: We hypothesized that maternal nutrition during the first 50 d of gestation would influence the abundance of hexose transporters, SLC2A1, SLC2A3, and SLC2A5, and cationic amino acid transporters, SLC7A1 and SLC7A2, in heifer utero-placental tissues.… read more here.
Keywords: gestation; acid transporters; amino acid; placental tissues ... See more keywords
Antitumor effects of novel mAbs against cationic amino acid transporter 1 (CAT1) on human CRC with amplified CAT1 gene
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DOI: 10.1111/cas.14741
Abstract: Copy number alterations detected by comparative genomic hybridization (CGH) can lead to the identification of novel cancer‐related genes. We analyzed chromosomal aberrations in a set of 100 human primary colorectal cancers (CRCs) using CGH and… read more here.
Keywords: cat1; cationic amino; crc; human crc ... See more keywords
The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity.
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DOI: 10.1242/jcs.249037
Abstract: Most tissues harbor a substantial population of resident macrophages. Here we elucidate a functional link between the Slc7a7 cationic amino acid transporter and tissue macrophages. We identified a mutant zebrafish devoid of microglia due to… read more here.
Keywords: amino acid; tissue macrophages; cationic amino; tissue ... See more keywords
Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009835
Abstract: Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large family of apicomplexan-specific plasma membrane-localized amino acid transporters, the ApiATs, and showed… read more here.
Keywords: amino; amino acids; cationic amino; toxoplasma gondii ... See more keywords