Chiral pH-sensitive cyclobutane β-amino acid-based cationic amphiphiles: Possible candidates for use in gene therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.111856
Abstract: Abstract Chiral cis/trans diastereomeric cationic amphiphiles have been synthesized and studied. They are based on β-amino acids and contain C12- and C16-alkyl chains, respectively, as hydrophobic tails while the polar head consists of an ammonium… read more here.
Keywords: amino; acid; gene therapy; cationic amphiphiles ... See more keywords
Serum Prevents Interactions between Antimicrobial Amphiphilic Aminoglycosides and Plasma Membranes.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00588
Abstract: Antimicrobial cationic amphiphiles have broad-spectrum activity, and microbes do not readily develop resistance to these agents, highlighting their clinical and industrial potential. Cationic amphiphiles perturb the integrity of membranes leading to cell death, and the… read more here.
Keywords: red blood; serum prevents; cationic amphiphiles; blood cells ... See more keywords
Phosphonodithioester–Amine Coupling as a Key Reaction Step for the Design of Cationic Amphiphiles Used for Gene Delivery
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247507
Abstract: A convergent synthesis of cationic amphiphilic compounds is reported here with the use of the phosphonodithioester–amine coupling (PAC) reaction. This versatile reaction occurs at room temperature without any catalyst, allowing binding of the lipid moiety… read more here.
Keywords: phosphonodithioester amine; delivery; amine coupling; cationic amphiphiles ... See more keywords