Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients.
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DOI: 10.1002/smll.202206968
Abstract: Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is associated with adverse effects. If these excipients are rapidly degraded to endogenously occurring metabolites such as amino acids and fatty… read more here.
Keywords: ionizable cationic; cationic ionizable; biodegradable cationic; cationic lipids ... See more keywords
Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines
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DOI: 10.3390/pharmaceutics15041173
Abstract: Africa bears the highest burden of infectious diseases, yet the continent is heavily reliant on First World countries for the development and supply of life-saving vaccines. The COVID-19 pandemic was a stark reminder of Africa’s… read more here.
Keywords: self amplifying; permanently cationic; cationic ionizable; delivery ... See more keywords