Serum Compatible Spermine‐Based Cationic Lipids with Nonidentical Hydrocarbon Tails Mediate High Transfection Efficiency
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100672
Abstract: Cationic lipids are widely used as nonviral synthetic vectors for gene delivery as a safer alternative to viral vectors. In this work, a library of L‐shaped spermine‐based cationic lipids with identical and nonidentical hydrophobic chains… read more here.
Keywords: nonidentical hydrocarbon; spermine based; based cationic; cationic lipids ... See more keywords
Optimizing Transfection Efficiency of Spermine Polar Head Cholesterol‐Based Cationic Lipids with Amino Acid Linker
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DOI: 10.1002/cbic.202400490
Abstract: In this work, a series of spermine polar head cholesterol‐based cationic lipids with various amino acid spacers were synthesized and evaluated as non‐viral gene delivery systems. The physicochemical properties of the resulting lipoplexes, formed from… read more here.
Keywords: cationic lipids; transfection efficiency; efficiency; amino acid ... See more keywords
Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients.
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DOI: 10.1002/smll.202206968
Abstract: Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is associated with adverse effects. If these excipients are rapidly degraded to endogenously occurring metabolites such as amino acids and fatty… read more here.
Keywords: ionizable cationic; cationic ionizable; biodegradable cationic; cationic lipids ... See more keywords
Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.11.022
Abstract: Despite the fact that small-sized lipid nanoparticles (LNPs) are important for improved tissue penetration and efficient drug delivery, their poor stability and intracellular trafficking significantly hinders their use as potent small-sized LNPs. It has been… read more here.
Keywords: cationic lipids; hydrophobic scaffolds; small sized; sensitive cationic ... See more keywords
Cationic lipids via multi-component Passerini reaction for non-viral gene delivery
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DOI: 10.1039/d3nj05949a
Abstract: Lipid Nanoparticles (LNPs) are the most advanced non-viral platform for nucleic acid delivery, holding enormous potential applications in clinical therapy. However, some shortcomings remain, such as complex synthetic routes, low... read more here.
Keywords: lipids via; delivery; non viral; via multi ... See more keywords
Reducible amino acid based cationic lipids with a naphthalimide moiety as non-viral gene vehicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Research"
DOI: 10.1177/17475198221145850
Abstract: Three basic amino acid–based cationic lipids bearing a fluorescent naphthalimide moiety and a reducible disulfide linkage are synthesized and applied as non-viral gene vehicles. Their DNA interactions are investigated by agarose-gel retardant and ethidium bromide… read more here.
Keywords: acid based; amino acid; cationic lipids; based cationic ... See more keywords