Preparation and Physical Characterization of DNA-Binding Cationic Liposomes.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6591-5_19
Abstract: DNA-binding cationic liposomes are routinely employed as one of the major non-viral transfecting agents delivering DNA and other genes inside the cells. Cationic liposomes when complexed with DNA form a strong positively charged liposome-DNA complex… read more here.
Keywords: binding cationic; technique; dna; physical characterization ... See more keywords
Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2966-6
Abstract: PurposeGOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.MethodsDuring the experiment, cationic liposomes with angiopep-2 (A2-CL)… read more here.
Keywords: glioma; golph3 sirna; glioma growth; cationic liposomes ... See more keywords
Evaluation of siRNA and cationic liposomes complexes as a model for in vitro siRNA delivery to cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2018.06.073
Abstract: Abstract Controlled release of genetic material such as small interfering RNA (siRNA) using lipid-based non-viral vectors has gained substantial importance in gene therapy applications. Therefore, the interaction between siRNA and these vectors must be well… read more here.
Keywords: sirna cationic; cationic liposomes; vitro; sirna ... See more keywords
Effects of cationic liposomes with stearylamine against virus infection
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.001
Abstract: &NA; In this study, we demonstrated that cationic liposomes with incorporated stearylamine (SA) inhibit viral infectivity without preloaded active pharmaceutical ingredients. Specifically, we correlated physiochemical properties of liposomes, such as zeta potentials and particle sizes,… read more here.
Keywords: stearylamine virus; infection; effects cationic; cationic liposomes ... See more keywords
Effect of cationic lipid type in cationic liposomes for siRNA delivery into the liver by sequential injection of chondroitin sulfate and cationic lipoplex
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.09.022
Abstract: Abstract Previously, we reported that intravenous injection of chondroitin sulfate (CS), followed by intravenous injection of cationic liposome/siRNA complex (cationic lipoplex) could deliver siRNA into the liver. In this study, we examined the effects of… read more here.
Keywords: type cationic; cationic lipid; cationic lipoplex; sequential injection ... See more keywords
Synthesis of protein conjugates adsorbed on cationic liposomes surface
Sign Up to like & getrecommendations! Published in 2020 at "MethodsX"
DOI: 10.1016/j.mex.2020.100942
Abstract: The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In… read more here.
Keywords: cpg odn; protein conjugates; chemistry; cationic liposomes ... See more keywords
Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Liposome Research"
DOI: 10.1080/08982104.2019.1630643
Abstract: Abstract RNA interference is a promising technology to inhibit the production of target proteins, and screening with synthetic small interfering RNA (siRNA) libraries has become a crucial research tool used to study gene function in… read more here.
Keywords: transfection; sirna lipoplexes; cationic liposomes; gene silencing ... See more keywords
Human papillomavirus Oncogene Manipulation Using Clustered Regularly Interspersed Short Palindromic Repeats/Cas9 Delivered by pH-Sensitive Cationic Liposomes.
Sign Up to like & getrecommendations! Published in 2020 at "Human gene therapy"
DOI: 10.1089/hum.2019.312
Abstract: CRISPR/Cas9 technology enables targeted gene editing, but cancer gene therapy with this approach requires improvements to enable safe and efficient delivery of CRISPR/Cas9 to tumors. We developed and evaluated a self-assembled liposome to selectively deliver… read more here.
Keywords: crispr cas9; sensitive cationic; cationic liposomes; human papillomavirus ... See more keywords
Influence of Liposomes’ and Lipoplexes’ Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116299
Abstract: Pregnant women are still considered as drug orphans. Developing new medications for pregnancy complications is an urgent need. Nanomedicines seem to be a promising approach to control the biodistribution of drugs to ensure both the… read more here.
Keywords: liposomes lipoplexes; internalization; mechanisms placenta; influence liposomes ... See more keywords
Immunostimulating RNA Delivered by P1500 PEGylated Cationic Liposomes Limits Influenza Infection in C57Bl/6 Mice
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12090875
Abstract: The emergence of highly pathogenic viruses and a high speed of infection spread put forward the problem of the development of novel antivirals and their delivery vehicles. In this study, we investigated the antiviral effect… read more here.
Keywords: isrna; infection; cationic liposomes; c57bl mice ... See more keywords
Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13091365
Abstract: Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications as vectors of nucleic acids (NAs), from long DNA and mRNA to short interfering RNA (siRNA), have been pursued for decades to… read more here.
Keywords: vectors nucleic; liposomes vectors; drug; cationic liposomes ... See more keywords