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   Articles with "catk" as a keyword



Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction.

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recommendations! Published in 2019 at "Journal of molecular and cellular cardiology"

DOI: 10.1016/j.yjmcc.2018.11.010

Abstract: BACKGROUND Extracellular matrix metabolism and cardiac cell death participate centrally in myocardial infarction (MI). This study tested the roles of collagenolytic cathepsin K (CatK) in post-MI left ventricular remodeling. METHODS AND RESULTS Patients with acute… read more here.

Keywords: catk; ctsk; days post; cardiac function ... See more keywords

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

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recommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2021.2024527

Abstract: Abstract Cathepsin K (CatK) is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is… read more here.

Keywords: highly potent; zymogen like; catk; differently positioned ... See more keywords

Cathepsin K: a novel association with glucose intolerance, insulin resistance, and subclinical atherosclerosis in T2DM

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recommendations! Published in 2025 at "Journal of Translational Medicine"

DOI: 10.1186/s12967-025-07079-w

Abstract: Cathepsin K (CatK) contributes to vessel collagene remodelling and high CatK concentrations have been found in atherosclerotic lesions. CatK ablation in a murine model determined an amelioration of diabetes-induced hyperglycemia and cardiovascular structural/functional abnormalities. To… read more here.

Keywords: t2dm; catk; catk levels; novel association ... See more keywords

Cathepsin K: The Action in and Beyond Bone

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recommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2020.00433

Abstract: Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug… read more here.

Keywords: catk; beyond bone; cathepsin; bone ... See more keywords