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   Articles with "catsper" as a keyword



Discovery and Characterization of Multiple Classes of Human CatSper Blockers

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recommendations! Published in 2022 at "Chemmedchem"

DOI: 10.1002/cmdc.202000499

Abstract: The cation channel of sperm (CatSper) is a validated target for nonhormonal male contraception, but it lacks selective blockers, hindering studies to establish its role in both motility and capacitation. Via an innovative calcium uptake… read more here.

Keywords: discovery characterization; characterization multiple; catsper blockers; catsper ... See more keywords

CatSper: A Unique Calcium Channel of the Sperm Flagellum.

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recommendations! Published in 2018 at "Current opinion in physiology"

DOI: 10.1016/j.cophys.2018.02.004

Abstract: To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation. The latter is triggered by a calcium influx through the sperm-specific,… read more here.

Keywords: catsper; calcium channel; channel; channel sperm ... See more keywords
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Tiny Dancer: EFCAB9 Triggers Sperm Hyperactivation via CatSper.

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recommendations! Published in 2019 at "Trends in biochemical sciences"

DOI: 10.1016/j.tibs.2019.08.001

Abstract: The Ca2+-conducting ion channel, CatSper, is expressed exclusively on the sperm flagellum and regulates sperm motility. A new study (Hwang et al., Cell, 2019) reveals that the pH-sensing and Ca2+-binding protein, EFCAB9, is a subunit… read more here.

Keywords: efcab9 triggers; catsper; tiny dancer; sperm hyperactivation ... See more keywords

Conservation of the Ca2+-permeability through the voltage sensor domain of mammalian CatSper subunit

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recommendations! Published in 2018 at "Channels"

DOI: 10.1080/19336950.2018.1476791

Abstract: ABSTRACT Cation channel of Spermatozoa (CatSper) is one of the voltage-gated ion channels consisting of voltage sensor domains (VSDs) and pore-gate domains. CatSper is exclusively expressed in spermatozoa and indispensable for Ca2+ influx into cytosol.… read more here.

Keywords: voltage; catsper; permeability; voltage sensor ... See more keywords

Both protein and non-protein components in extracellular vesicles of human seminal plasma improve human sperm function via CatSper-mediated calcium signaling.

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recommendations! Published in 2024 at "Human reproduction"

DOI: 10.1093/humrep/deae018

Abstract: STUDY QUESTION What is the significance and mechanism of human seminal plasma extracellular vesicles (EVs) in regulating human sperm functions? SUMMARY ANSWER EV increases the intracellular Ca2+ concentrations [Ca2+]i via extracellular Ca2+ influx by activating… read more here.

Keywords: catsper; human sperm; protein; seminal plasma ... See more keywords

O-120 The role of CatSper in male infertility - from bench to bedsite and back

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recommendations! Published in 2024 at "Human Reproduction"

DOI: 10.1093/humrep/deae108.135

Abstract: Infertility is on the rise, but the underlying causes still remain mostly unknown. In fact, for about one third of infertile men, semen parameters are within reference limits. This so called ‘unexplained male infertility’ seems… read more here.

Keywords: infertility; function; catsper; male infertility ... See more keywords

Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals

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recommendations! Published in 2018 at "Human Reproduction"

DOI: 10.1093/humrep/dey275

Abstract: STUDY QUESTION Does the chemosensory activation of CatSper Ca2+ channels in human sperm give rise to additive, sub-additive or even synergistic actions among agonists? SUMMARY ANSWER We show that oviductal ligands and endocrine disrupting chemicals… read more here.

Keywords: catsper; activation catsper; human sperm; ca2 ... See more keywords

Influence of antifertility agents Dutasteride and Nifedipine on CatSper gene level in epididymis during sperm maturation in BALB/c mice.

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recommendations! Published in 2018 at "Reproduction"

DOI: 10.1530/rep-17-0664

Abstract: Calcium (Ca2+) signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca2+ through CatSper (sperm-specific cation channel). The CatSper channel complex… read more here.

Keywords: antifertility agents; catsper; male; balb mice ... See more keywords

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.699554

Abstract: The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors, respectively.… read more here.

Keywords: steroids prostaglandins; catsper; human sperm; ca2 ... See more keywords