Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two‐Sample, Two‐Step Mendelian Randomization Study
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DOI: 10.1002/brb3.70412
Abstract: Emerging evidence from observational studies suggested that epigenetic age acceleration may result in an increased incidence of stroke and poorer functional outcomes after a stroke. However, the causality of these associations remains controversial and may… read more here.
Keywords: stroke functional; age; age acceleration; epigenetic age ... See more keywords
The Causal Relationship Between Neurotrophic Factors and Delirium: A Mendelian Randomization Study
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DOI: 10.1002/brb3.70494
Abstract: Several observational studies have revealed that different neurotrophic factors (NTFs) are associated with delirium, yet the direction and magnitude of the causal association remain poorly understood. Herein, we performed a two‐sample Mendelian randomization (MR) analysis… read more here.
Keywords: neurotrophic factors; causal relationship; mendelian randomization; causal ... See more keywords
Reducing bias in experimental ecology through directed acyclic graphs
Sign Up to like & getrecommendations! Published in 2023 at "Ecology and Evolution"
DOI: 10.1002/ece3.9947
Abstract: Abstract Ecologists often rely on randomized control trials (RCTs) to quantify causal relationships in nature. Many of our foundational insights of ecological phenomena can be traced back to well‐designed experiments, and RCTs continue to provide… read more here.
Keywords: ecology; acyclic graphs; reducing bias; causal ... See more keywords
Causal associations between sleep traits and four cardiac diseases: a Mendelian randomization study
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DOI: 10.1002/ehf2.14016
Abstract: Previous studies investigated the associations between sleep traits and cardiac diseases, but the evidence for the causal inferences was unclear. This study aimed to explore the causal relationship between sleep and cardiac diseases by virtue… read more here.
Keywords: cardiac diseases; mendelian randomization; causal; study ... See more keywords
Type 2 diabetes mellitus and cardiovascular health: Evidence of causal relationships in a European ancestry population
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DOI: 10.1002/ehf2.14877
Abstract: Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular disease (CVD) risk, but whether T2DM directly causes adverse cardiac remodelling is uncertain. We performed a comprehensive Mendelian randomization (MR) analysis to investigate the causal… read more here.
Keywords: mellitus cardiovascular; diabetes mellitus; type diabetes; causal ... See more keywords
Spatiotemporal Causal Inference With Mechanistic Ecological Models: Evaluating Targeted Culling on Chronic Wasting Disease Dynamics in Cervids
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DOI: 10.1002/env.2901
Abstract: Spatiotemporal causal inference methods are needed to detect the effect of interventions on indirectly measured epidemiological outcomes that go beyond studying spatiotemporal correlations. Chronic wasting disease (CWD) causes neurological degeneration and eventual death to white‐tailed… read more here.
Keywords: targeted culling; spatiotemporal causal; cwd; causal inference ... See more keywords
MR‐BOIL: Causal inference in one‐sample Mendelian randomization for binary outcome with integrated likelihood method
Sign Up to like & getrecommendations! Published in 2023 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22520
Abstract: Mendelian randomization is a statistical method for inferring the causal relationship between exposures and outcomes using an economics‐derived instrumental variable approach. The research results are relatively complete when both exposures and outcomes are continuous variables.… read more here.
Keywords: boil; mendelian randomization; causal; method ... See more keywords
Large‐scale dynamic causal modeling of major depressive disorder based on resting‐state functional magnetic resonance imaging
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DOI: 10.1002/hbm.24845
Abstract: Major depressive disorder (MDD) is a serious mental illness characterized by dysfunctional connectivity among distributed brain regions. Previous connectome studies based on functional magnetic resonance imaging (fMRI) have focused primarily on undirected functional connectivity and… read more here.
Keywords: depressive disorder; network; mdd; major depressive ... See more keywords
Comment on ‘A Causal Effect of Serum 25(OH)D Level on Appendicular Muscle Mass: Evidence From NHANES Data and Mendelian Randomization Analyses’ by Ren et al.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13855
Abstract: Serum 25-hydroxyvitamin D [25(OH)D] may enhance skeletal muscle metabolism and increase muscle mass through activation of vitamin D receptor pathways, reduction of oxidative stress and mitigation of mitochondrial dysfunction and cellular senescence. However, due to… read more here.
Keywords: serum; muscle mass; muscle; mendelian randomization ... See more keywords
Mendelian randomization study on the causal effects of COVID‐19 on childhood intelligence
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27736
Abstract: Although individuals with coronavirus disease 2019 (COVID‐19) are known to be at increased risk for other conditions resulting from pathogenic changes (including metaplastic or anaplastic) in the lungs and other organs and organ systems, it… read more here.
Keywords: intelligence; mendelian randomization; childhood intelligence; covid ... See more keywords
An integrated strategy to identify COVID‐19 causal genes and characteristics represented by LRRC37A2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28585
Abstract: Genome‐wide association study (GWAS) could identify host genetic factors associated with coronavirus disease 2019 (COVID‐19). The genes or functional DNA elements through which genetic factors affect COVID‐19 remain uncharted. The expression quantitative trait locus (eQTL)… read more here.
Keywords: strategy identify; integrated strategy; causal genes; causal ... See more keywords