An integrated strategy to identify COVID‐19 causal genes and characteristics represented by LRRC37A2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28585
Abstract: Genome‐wide association study (GWAS) could identify host genetic factors associated with coronavirus disease 2019 (COVID‐19). The genes or functional DNA elements through which genetic factors affect COVID‐19 remain uncharted. The expression quantitative trait locus (eQTL)… read more here.
Keywords: strategy identify; integrated strategy; causal genes; causal ... See more keywords
Prioritising Causal Genes at Type 2 Diabetes Risk Loci
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DOI: 10.1007/s11892-017-0907-y
Abstract: Purpose of ReviewGenome-wide association studies (GWAS) for type 2 diabetes (T2D) risk have identified a large number of genetic loci associated with disease susceptibility. However, progress moving from association signals through causal genes to functional… read more here.
Keywords: causal; type diabetes; prioritising causal; risk loci ... See more keywords
Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2019.03.026
Abstract: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. It shares clinical and pathological features with other types of dementia, such as vascular dementia (VaD), Lewy body dementia (LBD), and frontotemporal… read more here.
Keywords: dementia causal; early onset; alzheimer disease; causal ... See more keywords
Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Psychiatry"
DOI: 10.1038/s41380-022-01542-6
Abstract: Genome-wide association studies have discovered hundreds of genomic loci associated with psychiatric traits, but the causal genes underlying these associations are often unclear, a research gap that has hindered clinical translation. Here, we present a… read more here.
Keywords: high level; causal genes; etiology; genome wide ... See more keywords
Reply to Qiu et al.: Hunting for leadership “causal” genes: Mission possible?
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208115119
Abstract: showcase potential “ causal ” genes at genome-wide association study (GWAS) loci for leadership phenotypes, using expression quantitative trait loci (eQTL) mapping. Using the transcriptome-wide association study (TWAS) approach, the MST1R genetic region at chromosome… read more here.
Keywords: qiu hunting; causal genes; hunting leadership; reply qiu ... See more keywords
P13.06 Transcriptome-wide Mendelian randomization study to identify brain-specific causal genes influencing glioma
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.227
Abstract: The drug treatment regimen for glioma has remained relatively static since the introduction of temozolomide, although new drugs and drug combinations are being trialled. The human transcriptome can provide promising insights into causal genes as… read more here.
Keywords: glioma; drug; expression; brain ... See more keywords
Causal Gene Identification Using Non-Linear Regression-Based Independence Tests
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2022.3149864
Abstract: With the development of biomedical techniques in the past decades, causal gene identification has become one of the most promising applications in human genome-based business, which can help doctors to evaluate the risk of certain… read more here.
Keywords: mml mml; mml; disease; causal genes ... See more keywords
Burden tests can be used to map causal genes for a simple metabolic trait in an exome‐sequenced polyploid mutant population
Sign Up to like & getrecommendations! Published in 2022 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13890
Abstract: genetic screens are excellent tool to assign gene function, but it is often necessary to employ map-based cloning to identify the causal genes. This can be laborious and represents a bottleneck in in DNA it… read more here.
Keywords: burden tests; causal genes; exome sequenced; mutant population ... See more keywords
Identification of rheumatoid arthritis causal genes using functional genomics
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DOI: 10.1111/sji.12753
Abstract: Over the past decade, genome‐wide association studies have contributed a wealth of knowledge to our understanding of polygenic disorders such as rheumatoid arthritis. As the size of sample cohorts has improved so too have the… read more here.
Keywords: arthritis causal; identification rheumatoid; rheumatoid arthritis; arthritis ... See more keywords
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-221754
Abstract: Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and… read more here.
Keywords: risk seropositive; sequence; rheumatoid arthritis; causal genes ... See more keywords