Causal relationships between inflammatory factors and multiple myeloma: A bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34214
Abstract: Changes in serum inflammatory factors occur throughout the onset and multiple myeloma (MM) progression, the feedback loops make it harder to distinguish between causes and effects. In the present study, we performed a bidirectional summary‐level… read more here.
Keywords: mendelian randomization; inflammatory factors; multiple myeloma; causal relationships ... See more keywords
The bidirectional causal relationships of insomnia with five major psychiatric disorders: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2019 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2019.05.004
Abstract: Abstract Background: Several observational studies have investigated the association of insomnia with psychiatric disorders. Such studies yielded mixed results, and whether these associations are causal remains unclear. Thus, we aimed to identify the causal relationships… read more here.
Keywords: psychiatric disorders; disorder; relationships insomnia; insomnia five ... See more keywords
An analysis of causal relationships among challenges impeding redistributed manufacturing in emerging economies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cleaner Production"
DOI: 10.1016/j.jclepro.2019.04.011
Abstract: Abstract Constantly increasing wages and transportation costs with market uncertainty have initiated “re-shoring” programs and the establishment of low-scale localized production for advanced economies. For the purpose, Re-distributed Manufacturing (RdM) concept emerges as an essential… read more here.
Keywords: causal relationships; relationships among; analysis causal; among challenges ... See more keywords
Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits
Sign Up to like & getrecommendations! Published in 2018 at "Psychological Medicine"
DOI: 10.1017/s0033291718001812
Abstract: Abstract Background Cardiovascular diseases represent a major health issue in patients with schizophrenia (SCZ) and bipolar disorder (BD), but the exact nature of cardiometabolic (CM) abnormalities involved and the underlying mechanisms remain unclear. Psychiatric medications… read more here.
Keywords: exploring shared; genetic bases; bipolar disorder; shared genetic ... See more keywords
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome
Sign Up to like & getrecommendations! Published in 2022 at "Nature Genetics"
DOI: 10.1038/s41588-021-00968-y
Abstract: The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometric and blood… read more here.
Keywords: causal relationships; randomization analyses; gut microbiome; blood ... See more keywords
miRDDCR: a miRNA-based method to comprehensively infer drug-disease causal relationships
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15716-8
Abstract: Revealing the cause-and-effect mechanism behind drug-disease relationships remains a challenging task. Recent studies suggested that drugs can target microRNAs (miRNAs) and alter their expression levels. In the meanwhile, the inappropriate expression of miRNAs will lead… read more here.
Keywords: disease; drug; drug disease; disease causal ... See more keywords
Discordant Alpha-Band Transcranial Alternating Current Stimulation Affects Cortico-Cortical and Cortico-Cerebellar Connectivity
Sign Up to like & getrecommendations! Published in 2020 at "Brain connectivity"
DOI: 10.1089/brain.2019.0710
Abstract: Synchronization of oscillatory brain activity is believed to play a critical role in linking distributed neuronal populations into transient functional networks. 10-Hz alternating current stimulation (tACS) was applied over bilateral parietal cortex in a double-blind… read more here.
Keywords: stimulation; current stimulation; alternating current; brain ... See more keywords
Causal relationships between the gut microbiome, blood lipids, and heart failure: a Mendelian randomization analysis.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwad171
Abstract: BACKGROUND Studies have linked gut microbiome and heart failure (HF). However, their causal relationships and potential mediating factors have not been well defined. AIMS To investigate the causal relationships between the gut microbiome and HF… read more here.
Keywords: gut microbiome; analysis; causal; blood lipids ... See more keywords
Leveraging Genetic Discoveries for Sleep to Determine Causal Relationships with Common Complex Traits.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac180
Abstract: Sleep occurs universally and is a biological necessity for human functioning. The consequences of diminished sleep quality impact physical and physiological systems such as neurological, cardiovascular and metabolic processes. In fact, people impacted by common… read more here.
Keywords: common complex; causal; genetic discoveries; causal relationships ... See more keywords
Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1101/2022.03.02.482630
Abstract: To infer a causal relationship between two traits, several correlation-based causal direction (CD) methods have been proposed with the use of SNPs as instrumental variables (IVs) based on GWAS summary data for the two traits;… read more here.
Keywords: presence; directional causal; gwas summary; correlated pleiotropy ... See more keywords
Environmental Justice: Establishing Causal Relationships
Sign Up to like & getrecommendations! Published in 2019 at "Annual Review of Resource Economics"
DOI: 10.1146/annurev-resource-100518-094131
Abstract: The environmental justice literature has found that the poor and people of color are disproportionately exposed to pollution. This literature has sparked a broad activist movement and several policy reforms in the United States and… read more here.
Keywords: causal relationships; justice; environmental justice; economics ... See more keywords