GESLM algorithm for detecting causal SNPs in GWAS with multiple phenotypes.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab276
Abstract: With the development of genome-wide association studies, how to gain information from a large scale of data has become an issue of common concern, since traditional methods are not fully developed to solve problems such… read more here.
Keywords: genome wide; detecting causal; causal snps; geslm algorithm ... See more keywords
Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1009483
Abstract: The number of variants that have a non-zero effect on a trait (i.e. polygenicity) is a fundamental parameter in the study of the genetic architecture of a complex trait. Although many previous studies have investigated… read more here.
Keywords: causal snps; architecture complex; regional polygenicity; genetic architecture ... See more keywords
STS-BN: An efficient Bayesian network method for detecting causal SNPs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.942464
Abstract: Background: The identification of the causal SNPs of complex diseases in large-scale genome-wide association analysis is beneficial to the studies of pathogenesis, prevention, diagnosis and treatment of these diseases. However, existing applicable methods for large-scale… read more here.
Keywords: method; network; bayesian network; causal snps ... See more keywords