Addressing Causality and Homogeneity Assumptions in Exposure-Response Analyses.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.70132
Abstract: Exposure-response, or pharmacokinetic-pharmacodynamic (PKPD), analyses support many drug development decisions. It is typically applied without assessment of causality and homogeneity, where the latter refers to the assumption that the reason for variability in exposure is… read more here.
Keywords: causality homogeneity; response; exposure response; model ... See more keywords