Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer.
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DOI: 10.1158/0008-5472.can-22-2525
Abstract: Understanding functional interactions between cancer mutations is an attractive strategy for discovering unappreciated cancer pathways and developing new combination therapies to improve personalized treatment. However, distinguishing driver gene pairs from passenger pairs remains challenging. Here,… read more here.
Keywords: breast; mitochondrial translation; caused cbfb; breast cancer ... See more keywords