Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
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DOI: 10.1097/j.pain.0000000000001524
Abstract: Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels… read more here.
Keywords: targeting cav; cav interaction; cav cav; cav ... See more keywords