The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23723
Abstract: Throughout life, oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes. OPCs express cell surface receptors and channels that allow them to detect and respond to neuronal activity, including voltage‐gated calcium channel (VGCC)s. The… read more here.
Keywords: channel; gated calcium; cav1; cell ... See more keywords
Caveolin and lipid domains–close companions in managing cellular pathways
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09891-w
Abstract: Identification of lipid rafts (highly dynamic plasma membrane domains enriched in cholesterol and sphingolipids) and caveolae, a subdomain of lipid rafts, established a foundation for a remarkable period of multidisciplinary research on the molecular and… read more here.
Keywords: caveolae; caveolin; cav1; cancer ... See more keywords
Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.11.034
Abstract: Summary Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous… read more here.
Keywords: metastasis; cav1; associated macrophages; growth ... See more keywords
Human native Cav1 channels in chromaffin cells: contribution to exocytosis and firing of spontaneous action potentials
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2016.12.009
Abstract: ABSTRACT The present study was performed to evaluate the Cav1 channel subtypes expressed in human chromaffin cells and the role that these channels play in exocytosis and cell excitability. Here we show that human chromaffin… read more here.
Keywords: chromaffin cells; contribution; spontaneous action; cav1 ... See more keywords
Rapid Turnover of the Cardiac L-Type CaV1.2 Channel by Endocytic Recycling Regulates Its Cell Surface Availability
Sign Up to like & getrecommendations! Published in 2018 at "iScience"
DOI: 10.1016/j.isci.2018.08.012
Abstract: Summary Calcium entry through CaV1.2 L-type calcium channels regulates cardiac contractility. Here, we study the impact of exocytic and post-endocytic trafficking on cell surface channel abundance in cardiomyocytes. Single-molecule localization and confocal microscopy reveal an… read more here.
Keywords: endocytic recycling; channel; cav1; surface availability ... See more keywords
Mn2+ dynamics in manganese-enhanced MRI (MEMRI): Cav1.2 channel-mediated uptake and preferential accumulation in projection terminals
Sign Up to like & getrecommendations! Published in 2018 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2017.12.054
Abstract: ABSTRACT Manganese‐enhanced magnetic resonance imaging (MEMRI) exploits the biophysical similarity of Ca2+ and Mn2+ to map the brain's activity in vivo. However, to what extent different Ca2+ channels contribute to the enhanced signal that MEMRI… read more here.
Keywords: accumulation; mn2; cav1; projection terminals ... See more keywords
Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of CaV1.3 Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00889
Abstract: Cyclic α-aryl β-dicarbonyl derivatives are important scaffolds in medicinal chemistry. Palladium-catalyzed coupling reactions of haloarenes were conducted with diverse five- to seven-membered cyclic β-dicarbonyl derivatives including barbiturate, pyrazolidine-3,5-dione, and 1,4-diazepane-5,7-dione. The coupling reactions of various… read more here.
Keywords: cyclic dicarbonyl; cav1; palladium catalyzed; dione ... See more keywords
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3813
Abstract: Caveolin-1 (Cav1) regulates the nanoscale organization and compartmentalization of the plasma membrane. Here we found that Cav1 controlled the distribution of nanoclusters of isotype-specific B cell antigen receptors (BCRs) on the surface of B cells.… read more here.
Keywords: bcr; nanoscale organization; caveolin dependent; cav1 ... See more keywords
Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.266
Abstract: It has previously been shown that the inhibition of L-type calcium channels (LTCCs) decreases alcohol consumption, although the contribution of the central LTCC subtypes Cav1.2 and Cav1.3 remains unknown. Here, we determined changes in Cav1.2… read more here.
Keywords: dependence; type calcium; cav1; calcium ... See more keywords
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1242-3
Abstract: Caveolin-1 (CAV1) enhanced migration, invasion, and metastasis of cancer cells is inhibited by co-expression of the glycoprotein E-cadherin. Although the two proteins form a multiprotein complex that includes β-catenin, it remained unclear how this would… read more here.
Keywords: tyrosine phosphatase; metastasis; cav1; cancer ... See more keywords
Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07608-w
Abstract: Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although HER2 is a cell membrane receptor, differential rates of endocytosis and recycling… read more here.
Keywords: trastuzumab binding; cell membrane; her2 cell; cav1 ... See more keywords