Exercise during pregnancy enhances vascular function via epigenetic repression of CaV1.2 channel in offspring of hypertensive rats.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116576
Abstract: AIMS Studies suggest that cardiovascular function in offspring can be epigenetically programmed by environmental changes during pregnancy. CaV1.2 channel plays a major role in the regulation of the vascular tone. This study investigated the effects… read more here.
Keywords: channel; offspring hypertensive; exercise pregnancy; cav1 channel ... See more keywords
Amyloid-beta peptide potentiates vascular Cav1.2 channel activity
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5727832
Abstract: Alzheimer’s disease (AD), the most common form of dementia, affects over 6 million Americans and has devastating emotional and physical consequences for both the patient and surrounding loved ones. Current drug therapies are principally targeted… read more here.
Keywords: physiology; vascular cav1; channel activity; cav1 channel ... See more keywords
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20080515
Abstract: Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareolide, this molecule was… read more here.
Keywords: labdane; cav1 channel; novel labdane; diterpenes based ... See more keywords