Optically Probing the Mechanism of Voltage-Dependent Facilitation in CaV1.2 Channels
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DOI: 10.1016/j.bpj.2016.11.1337
Abstract: An important regulatory mechanism of excitation-evoked Ca2+ influx is voltage-dependent, or pre-pulse, facilitation (VDF): a memory property of some CaV channels, whereby channel activation is enhanced following a pre-conditioning pulse of sufficient duration and amplitude.… read more here.
Keywords: voltage; mechanism; facilitation; voltage dependent ... See more keywords
Human native Cav1 channels in chromaffin cells: contribution to exocytosis and firing of spontaneous action potentials
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DOI: 10.1016/j.ejphar.2016.12.009
Abstract: ABSTRACT The present study was performed to evaluate the Cav1 channel subtypes expressed in human chromaffin cells and the role that these channels play in exocytosis and cell excitability. Here we show that human chromaffin… read more here.
Keywords: chromaffin cells; contribution; spontaneous action; cav1 ... See more keywords
Loss of Cav1.2 channels impairs hippocampal theta burst stimulation-induced long-term potentiation
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DOI: 10.1080/19336950.2020.1807851
Abstract: ABSTRACT CACNA1 C, which codes for the Cav1.2 isoform of L-type Ca2+ channels (LTCCs), is a prominent risk gene in neuropsychiatric and neurodegenerative conditions. A role forLTCCs, and Cav1.2 in particular, in transcription-dependent late long-term… read more here.
Keywords: term potentiation; long term; theta burst; cav1 ... See more keywords
Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage
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DOI: 10.7554/elife.28029
Abstract: CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that… read more here.
Keywords: voltage; proximal clustering; cav1 channels; activation ... See more keywords