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   Articles with "cav2" as a keyword



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Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking

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recommendations! Published in 2019 at "Molecular Neurobiology"

DOI: 10.1007/s12035-019-01711-9

Abstract: Cocaine addiction remains a major health concern with limited effective treatment options. A better understanding of mechanisms underlying relapse may help inform the development of new pharmacotherapies. Emerging evidence suggests that collapsin response mediator protein… read more here.

Keywords: crmp2; cocaine seeking; reinstatement cocaine; cocaine ... See more keywords
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Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury

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recommendations! Published in 2018 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2018.04.016

Abstract: N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where… read more here.

Keywords: drg neurons; drgs; dorsal root; upregulation ... See more keywords
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Neuronal calcium channel α1 subunit interacts with AMPA receptor, increasing its cell surface localisation.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.02.107

Abstract: Voltage-activated Ca2+ channels (Cav) play critical roles in excitable cells including neurons. Unlike the well-defined roles of Cav2 for pre-synaptic neurotransmission, the post-synaptic function of Cav2 is unclear. Based on our previous study demonstrating the… read more here.

Keywords: cav2 ampa; ampa; surface localisation; ampa receptor ... See more keywords
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Direct inhibition of CaV2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.11.052

Abstract: The Rad, Rem, Rem2, and Gem/Kir (RGK) sub-family of small GTP-binding proteins are crucial in regulating high voltage-activated (HVA) calcium channels. RGK proteins inhibit calcium current by either promoting endocytosis or reducing channel activity. They… read more here.

Keywords: gem; dynamin dependent; inhibition cav2; cav2 channels ... See more keywords
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A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis.

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recommendations! Published in 2021 at "European journal of cancer"

DOI: 10.1016/j.ejca.2021.04.008

Abstract: AIM This study aimed to identify the functional genes and genetic variants associated with the prognosis of pancreatic ductal adenocarcinoma (PDAC) and reveal the mechanism underlying their prognostic roles. METHODS First, we implement a two-stage… read more here.

Keywords: prognosis; genetic variant; expression; progression ... See more keywords

Calmodulin modulates the Ca2+-dependent inactivation and expression level of bovine CaV2.2 expressed in HEK293T cells

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recommendations! Published in 2017 at "IBRO Reports"

DOI: 10.1016/j.ibror.2017.03.002

Abstract: Ca2+ influx through voltage-gated Ca2+ channels (CaVs) at the plasma membrane is the major pathway responsible for the elevation of the intracellular Ca2+ concentration ([Ca2+]i), which activates various physiological activities. Calmodulin (CaM) is known to… read more here.

Keywords: cam; cav2 expressed; level; inactivation ... See more keywords
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Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

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recommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1811024115

Abstract: Significance Influx of calcium ions through surface membrane calcium channels that open in response to electrical signals is important for vital biological processes including generation of the heartbeat and nerve cell communication. Blocking such calcium… read more here.

Keywords: calcium channels; rgk; cav1; cav2 ... See more keywords
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In vitro and in vivo phosphorylation of the Cav2.3 voltage-gated R-type calcium channel

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recommendations! Published in 2018 at "Channels"

DOI: 10.1080/19336950.2018.1516984

Abstract: ABSTRACT During the recording of whole cell currents from stably transfected HEK-293 cells, the decline of currents carried by the recombinant human Cav2.3+β3 channel subunits is related to adenosine triphosphate (ATP) depletion after rupture of… read more here.

Keywords: vitro vivo; channel; phosphorylation cav2; vivo phosphorylation ... See more keywords
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miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels

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recommendations! Published in 2017 at "Pain"

DOI: 10.1097/j.pain.0000000000000971

Abstract: Abstract Pathophysiological mechanisms underlying pain associated with cancer are poorly understood. microRNAs (miRNAs) are a class of noncoding RNAs with emerging functional importance in chronic pain. In a genome-wide screen for miRNAs regulated in dorsal… read more here.

Keywords: cancer pain; sensory neurons; cav2; pain ... See more keywords
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Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

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recommendations! Published in 2019 at "Pain"

DOI: 10.1097/j.pain.0000000000001524

Abstract: Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels… read more here.

Keywords: targeting cav; cav interaction; cav cav; cav ... See more keywords
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Nerve injury increases native CaV2.2 trafficking in dorsal root ganglion mechanoreceptors

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recommendations! Published in 2022 at "Pain"

DOI: 10.1097/j.pain.0000000000002846

Abstract: Supplemental Digital Content is Available in the Text. Using a CaV2.2_HA knockin mouse, it was found that following nerve injury, CaV2.2_HA increases in medium/large dorsal root ganglion neurons and deep dorsal horn, associated with GFRα1. read more here.

Keywords: nerve injury; cav2; root ganglion; dorsal root ... See more keywords